Show simple item record

dc.contributor.authorIrani, Soussan
dc.contributor.authorSalajegheh, Ali
dc.contributor.authorSmith, Robert Anthony
dc.contributor.authorLam, Alfred King-Yin
dc.date.accessioned2017-11-22T12:00:41Z
dc.date.available2017-11-22T12:00:41Z
dc.date.issued2014
dc.date.modified2014-09-04T04:25:45Z
dc.identifier.issn1040-8428
dc.identifier.doi10.1016/j.critrevonc.2013.08.011
dc.identifier.urihttp://hdl.handle.net/10072/62402
dc.description.abstractThe endothelins and their associated receptors are important controllers of vascular growth, inflammation and vascular tone. In cancer, they have roles in the control of numerous factors in cancer development and progression, including angiogenesis, stromal reaction, epithelial mesenchymal transitions, apoptosis, invasion, metastases and drug resistance. Also, we consider current information on the role of this signalling system in cancer and examine the state of the current cell, animal and clinical trials utilizing endothelin targeted drugs for cancer management. Although targeting the endothelin axis in cell lines and xenografts show some promise in retarding cellular growth, results from limited clinical trials in prostatic cancer are less encouraging and did not offer significant survival benefit. The ability to target both cancer cells and vasculature via endothelin is an important consideration that necessitates the further refining of therapeutic strategies as we continue to explore the possibilities of the endothelin axis in cancer treatment.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent345660 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeIreland
dc.relation.ispartofstudentpublicationY
dc.relation.ispartofpagefrom314
dc.relation.ispartofpageto321
dc.relation.ispartofissue2
dc.relation.ispartofjournalCritical Reviews in Oncology Hematology
dc.relation.ispartofvolume89
dc.rights.retentionY
dc.subject.fieldofresearchCardiovascular medicine and haematology
dc.subject.fieldofresearchOncology and carcinogenesis
dc.subject.fieldofresearchcode3201
dc.subject.fieldofresearchcode3211
dc.titleA review of the profile of endothelin axis in cancer and its management
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Health, School of Medicine
gro.rights.copyright© 2014 Elsevier. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
gro.date.issued2014
gro.hasfulltextFull Text
gro.griffith.authorLam, Alfred K.
gro.griffith.authorAriana, Armin S.


Files in this item

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record