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dc.contributor.authorBarclay, Chrisen_US
dc.date.accessioned2017-04-24T08:34:44Z
dc.date.available2017-04-24T08:34:44Z
dc.date.issued2003en_US
dc.date.modified2009-02-25T08:02:48Z
dc.identifier.issn01418130en_US
dc.identifier.doi10.1016/S0141-8130(03)00047-3en_AU
dc.identifier.urihttp://hdl.handle.net/10072/6244
dc.description.abstractContractile filaments in skeletal muscle are moved by less than 2 nm for each ATP used. If just one cross-bridge is attached to each thin filament at any instant then this distance represents the fundamental myosin cross-bridge step size (i.e. the distance one cross-bridge moves a thin filament in one ATP-splitting cycle). However, most contraction models assume many cross-bridges are attached at any instant along each thin filament. The purpose of this study was to establish whether the net filament sliding per ATP used could be explained quantitatively in terms of a cross-bridge model in which multiple cross-bridges are attached along each thin filament. It was found that the relationship between net filament sliding per ATP split and the load against which the muscle shortens is compatible with such a model and furthermore predicts that the cross-bridge step size is between 7.5 and 12.5 nm over most of the range of loads. These values were similar for different muscle fibre types.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherElsevier Science BVen_US
dc.publisher.placeNetherlandsen_US
dc.publisher.urihttp://www.elsevier.com/wps/find/journaldescription.cws_home/525446/description#descriptionen_AU
dc.relation.ispartofpagefrom139en_US
dc.relation.ispartofpageto147en_US
dc.relation.ispartofissue3-5en_US
dc.relation.ispartofjournalInternational Journal of Biological Macromoleculesen_US
dc.relation.ispartofvolume32en_US
dc.subject.fieldofresearchcode270602en_US
dc.titleModels in which many cross-bridges attach simultaneously can explain the filament movement per ATP split during muscle contractionen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.facultyGriffith Health, School of Rehabilitation Sciencesen_US
gro.rights.copyrightCopyright 2003 Elsevier : Reproduced in accordance with the copyright policy of the publisher : This journal is available online - use hypertext links.en_AU
gro.date.issued2003
gro.hasfulltextNo Full Text


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