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dc.contributor.authorSautron, C.en_US
dc.contributor.authorCock, Ianen_US
dc.date.accessioned2017-05-03T11:28:49Z
dc.date.available2017-05-03T11:28:49Z
dc.date.issued2014en_US
dc.date.modified2014-08-19T04:42:11Z
dc.identifier.issn22490159en_US
dc.identifier.urihttp://hdl.handle.net/10072/62510
dc.description.abstractIntroduction: Many species of Syzygium are known to have antiseptic activity. Several Australian Syzygium species had roles as traditional bush medicines for Australian Aborigines although their antiseptic potential has not been rigorously studied. Methods: The antimicrobial activity of solvent extracts of Syzygium australe and Syzygium leuhmannii fruits were investigated by disc diffusion assay against a panel of bacteria and fungi and their MIC values were determined. Toxicity was determined using the Artemia franciscana nauplii bioassay. Results: The methanolic extracts of the fruit of both Syzygium species displayed the greater antibacterial activity of the extracts tested. S. australe generally had greater efficacy than the S. leuhmannii extracts. S. australe and S. leuhmannii fruit methanolic extract inhibited the growth of 13 (93 %) and 12 (86 %) of the 14 bacteria tested. Gram-positive and Gram-negative bacteria were both susceptible, although a slightly greater susceptibility of Gram-positive bacteria was noted. Nine (90 %) and 8 (80 %) of the 10 Gram-negative bacteria had their growth inhibited by S. australe and S. leuhmannii fruit methanolic extract extracts respectively. In contrast, methanolic extracts of both species inhibited growth of 100 % of the Gram-positive bacteria tested. None of the extracts displayed broad antifungal activity. Indeed, none of the extracts inhibited the growth of A. niger or C. albicans. Only S. cerevisiae growth was affected and then only by the chloroform and hexane extracts. The methanolic, aqueous and ethyl acetate extracts of both Syzygium species were toxic in the Artemia franciscana bioassay, inducing significant mortality at <1000 姯ml. Conclusions: The inhibitory bioactivity of S. australe against the bacterial panel validate Australian Aboriginal usage of S. australe leaves as antiseptic agents and confirms their medicinal potential, although care is needed in the uses of these extracts for these purposes due to their reported toxicity.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_US
dc.format.extent1144059 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglishen_US
dc.publisherPhcog.neten_US
dc.publisher.placeIndiaen_US
dc.publisher.urihttp://www.phcog.net/content/pharmacognosy-communicationsen_US
dc.relation.ispartofstudentpublicationNen_US
dc.relation.ispartofpagefrom53en_US
dc.relation.ispartofpageto60en_US
dc.relation.ispartofissue1en_US
dc.relation.ispartofjournalPharmacognosy Communicationsen_US
dc.relation.ispartofvolume4en_US
dc.rights.retentionYen_US
dc.subject.fieldofresearchComplementary and Alternative Medicine not elsewhere classifieden_US
dc.subject.fieldofresearchcode110499en_US
dc.titleAntimicrobial Activity and Toxicity of Syzygium australe and Syzygium leuhmannii Fruit Extractsen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.rights.copyright© 2014 Phcog.net. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.en_US
gro.hasfulltextFull Text
gro.griffith.authorCock, Ian E.


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