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dc.contributor.authorSautron, C.
dc.contributor.authorCock, Ian
dc.date.accessioned2017-05-03T11:28:49Z
dc.date.available2017-05-03T11:28:49Z
dc.date.issued2014
dc.date.modified2014-08-19T04:42:11Z
dc.identifier.issn22490159
dc.identifier.urihttp://hdl.handle.net/10072/62510
dc.description.abstractIntroduction: Many species of Syzygium are known to have antiseptic activity. Several Australian Syzygium species had roles as traditional bush medicines for Australian Aborigines although their antiseptic potential has not been rigorously studied. Methods: The antimicrobial activity of solvent extracts of Syzygium australe and Syzygium leuhmannii fruits were investigated by disc diffusion assay against a panel of bacteria and fungi and their MIC values were determined. Toxicity was determined using the Artemia franciscana nauplii bioassay. Results: The methanolic extracts of the fruit of both Syzygium species displayed the greater antibacterial activity of the extracts tested. S. australe generally had greater efficacy than the S. leuhmannii extracts. S. australe and S. leuhmannii fruit methanolic extract inhibited the growth of 13 (93 %) and 12 (86 %) of the 14 bacteria tested. Gram-positive and Gram-negative bacteria were both susceptible, although a slightly greater susceptibility of Gram-positive bacteria was noted. Nine (90 %) and 8 (80 %) of the 10 Gram-negative bacteria had their growth inhibited by S. australe and S. leuhmannii fruit methanolic extract extracts respectively. In contrast, methanolic extracts of both species inhibited growth of 100 % of the Gram-positive bacteria tested. None of the extracts displayed broad antifungal activity. Indeed, none of the extracts inhibited the growth of A. niger or C. albicans. Only S. cerevisiae growth was affected and then only by the chloroform and hexane extracts. The methanolic, aqueous and ethyl acetate extracts of both Syzygium species were toxic in the Artemia franciscana bioassay, inducing significant mortality at <1000 姯ml. Conclusions: The inhibitory bioactivity of S. australe against the bacterial panel validate Australian Aboriginal usage of S. australe leaves as antiseptic agents and confirms their medicinal potential, although care is needed in the uses of these extracts for these purposes due to their reported toxicity.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent1144059 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherPhcog.net
dc.publisher.placeIndia
dc.publisher.urihttp://www.phcog.net/content/pharmacognosy-communications
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom53
dc.relation.ispartofpageto60
dc.relation.ispartofissue1
dc.relation.ispartofjournalPharmacognosy Communications
dc.relation.ispartofvolume4
dc.rights.retentionY
dc.subject.fieldofresearchComplementary and Alternative Medicine not elsewhere classified
dc.subject.fieldofresearchPlant Biology
dc.subject.fieldofresearchPharmacology and Pharmaceutical Sciences
dc.subject.fieldofresearchcode110499
dc.subject.fieldofresearchcode0607
dc.subject.fieldofresearchcode1115
dc.titleAntimicrobial Activity and Toxicity of Syzygium australe and Syzygium leuhmannii Fruit Extracts
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.rights.copyright© 2014 Phcog.net. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
gro.hasfulltextFull Text
gro.griffith.authorCock, Ian E.


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