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dc.contributor.authorZhong, Zhaoxi
dc.contributor.authorZhao, Tengda
dc.contributor.authorLuo, Jia
dc.contributor.authorGuo, Zhihua
dc.contributor.authorGuo, Meng
dc.contributor.authorLi, Ping
dc.contributor.authorSun, Jing
dc.contributor.authorHe, Yong
dc.contributor.authorLi, Zhanjiang
dc.contributor.editorGuy Drolet
dc.date.accessioned2017-05-03T15:17:33Z
dc.date.available2017-05-03T15:17:33Z
dc.date.issued2014
dc.date.modified2014-08-19T04:42:37Z
dc.identifier.issn0278-5846
dc.identifier.doi10.1016/j.pnpbp.2014.01.005
dc.identifier.urihttp://hdl.handle.net/10072/62521
dc.description.abstractBackground: Obsessive-compulsive disorder (OCD) is a chronic psychiatric disorder defined by recurrent thoughts, intrusive and distressing impulses, or images and ritualistic behaviors. Although focal diverse regional abnormalities white matter integrity in specific brain regions have beenwidely studied in populationswith OCD, alterations in the structural connectivities among them remain poorly understood. Objective: The aimwas to investigate the abnormalities in the topological efficiency of thewhite matter networks and the correlation between the networkmetrics and Yale-BrownObsessive-Compulsive Scale scores in unmedicated OCD patients, using diffusion tensor tractography and graph theoretical approaches. Methods: This study used diffusion tensor imaging and deterministic tractography to map the white matter structural networks in 26 OCD patients and 39 age- and gender-matched healthy controls; and then applied graph theoretical methods to investigate abnormalities in the global and regional properties of the white matter network in these patients. Results: The patients and control participants both showed small-world organization of the white matter networks. However, the OCD patients exhibited significant abnormal global topology, including decreases in global efficiency (t = -2.32, p = 0.02) and increases in shortest path length, Lp (t= 2.30, p = 0.02), the normalized weighted shortest path length, ? (t = 2.08, p = 0.04), and the normalized clustering coefficient, ? (t = 2.26, p = 0.03), of their white matter structural networks compared with healthy controls. Further, the OCD patients showed a reduction in nodal efficiency predominately in the frontal regions, the parietal regions and caudate nucleus. The normalized weighted shortest path length of the network metrics was significantly negatively correlated with obsessive subscale of the Yale-Brown Obsessive-Compulsive Scale (r = -0.57, p= 0.0058). Conclusions: These findings demonstrate the abnormal topological efficiency in the white matter networks in OCD patients.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom39
dc.relation.ispartofpageto50
dc.relation.ispartofjournalProgress in Neuro-Psychopharmacology & Biological Psychiatry
dc.relation.ispartofvolume51
dc.rights.retentionY
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchNeurosciences
dc.subject.fieldofresearchNeurosciences not elsewhere classified
dc.subject.fieldofresearchPsychology
dc.subject.fieldofresearchBiochemistry and cell biology
dc.subject.fieldofresearchcode32
dc.subject.fieldofresearchcode3202
dc.subject.fieldofresearchcode3209
dc.subject.fieldofresearchcode320999
dc.subject.fieldofresearchcode52
dc.subject.fieldofresearchcode3101
dc.titleAbnormal topological organization in white matter structural networks revealed by diffusion tensor tractography in unmedicated patients with obsessive–compulsive disorder
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorSun, Jing


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