Show simple item record

dc.contributor.authorHoelzer, Karin
dc.contributor.authorMurcia, Pablo R.
dc.contributor.authorBaillie, Gregory J.
dc.contributor.authorWood, James L. N.
dc.contributor.authorMetzger, Stephan M.
dc.contributor.authorOsterrieder, Nikolaus
dc.contributor.authorDubovi, Edward J.
dc.contributor.authorHolmes, Edward C.
dc.contributor.authorParrish, Colin R.
dc.date.accessioned2017-05-03T12:44:53Z
dc.date.available2017-05-03T12:44:53Z
dc.date.issued2010
dc.date.modified2014-08-19T04:42:44Z
dc.identifier.issn0022538X
dc.identifier.doi10.1128/JVI.02469-09
dc.identifier.urihttp://hdl.handle.net/10072/62526
dc.description.abstractThe patterns and dynamics of evolution in acutely infecting viruses within individual hosts are largely unknown. To this end, we investigated the intrahost variation of canine influenza virus (CIV) during the course of experimental infections in naﶥ and partially immune dogs and in naturally infected dogs. Tracing sequence diversity in the gene encoding domain 1 of the hemagglutinin (HA1) protein over the time course of infection provided information on the patterns and processes of intrahost viral evolution and revealed some of the effects of partial host immunity. Viral populations sampled on any given day were generally characterized by mean pairwise genetic diversities between 0.1 and 0.2% and by mutational spectra that changed considerably on different days. Some observed mutations may have affected antigenicity or host range, including reversions of CIV host-associated mutations. Patterns of sequence diversity differed between naﶥ and vaccinated dogs, with some presumably antigenic mutations transiently reaching high frequency in the latter. CIV populations are therefore characterized by the rapid generation and clearance of genetic diversity. Potentially advantageous mutations arise readily during the course of single infections and may give rise to antigenic escape or host range variants.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.publisherAmerican Society for Microbiology
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom5329
dc.relation.ispartofpageto5335
dc.relation.ispartofissue10
dc.relation.ispartofjournalJournal of Virology
dc.relation.ispartofvolume84
dc.rights.retentionY
dc.subject.fieldofresearchBiological Sciences not elsewhere classified
dc.subject.fieldofresearchBiological Sciences
dc.subject.fieldofresearchAgricultural and Veterinary Sciences
dc.subject.fieldofresearchMedical and Health Sciences
dc.subject.fieldofresearchcode069999
dc.subject.fieldofresearchcode06
dc.subject.fieldofresearchcode07
dc.subject.fieldofresearchcode11
dc.titleIntrahost Evolutionary Dynamics of Canine Influenza Virus in Naïve and Partially Immune Dogs
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorBaillie, Greg


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record