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dc.contributor.authorJ. Baillie, Gregory
dc.contributor.authorKolokotronis, Sergios-Orestis
dc.contributor.authorWaltari, Eric
dc.contributor.authorG. Maffei, Joseph
dc.contributor.authorD. Kramer, Laura
dc.contributor.authorL. Perkins, Susan
dc.date.accessioned2017-05-03T12:44:53Z
dc.date.available2017-05-03T12:44:53Z
dc.date.issued2008
dc.date.modified2014-08-19T04:43:17Z
dc.identifier.issn1055-7903
dc.identifier.doi10.1016/j.ympev.2008.02.015
dc.identifier.urihttp://hdl.handle.net/10072/62541
dc.description.abstractSt. Louis encephalitis virus belongs to the Japanese encephalitis virus serocomplex of the genus Flavivirus, family Flaviviridae. Since the first known epidemic in 1933, the virus has been isolated from a variety of geographical, temporal, and host origins. We have sequenced 10,236 nucleotides of the open reading frame (93.6% of the full-length genome) of 23 of these strains, and have used the sequences to conduct phylogenetic analyses, in order to investigate the forces shaping the evolution of St. Louis encephalitis virus. Contrary to previous reports, we found little evidence for recombination in these isolates. Most of the amino acid sites in the SLEV polyprotein appeared to be under negative selection, with some sites evolving neutrally, and a small number under positive selection. The strongest signal for positive selection was evident in the N-linked glycosylation site of the envelope protein. Intra-strain sequence variability within strains was observed at this site, and analyses suggested that it is under selection in vitro. Furthermore, using heterochronous sequence data, we estimated the most recent expansion of St. Louis encephalitis virus in North America to have happened towards the end of the 19th century.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherAcademic Press
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom717
dc.relation.ispartofpageto728
dc.relation.ispartofissue2
dc.relation.ispartofjournalMolecular Phylogenetics and Evolution
dc.relation.ispartofvolume47
dc.rights.retentionY
dc.subject.fieldofresearchEvolutionary Biology not elsewhere classified
dc.subject.fieldofresearchEvolutionary Biology
dc.subject.fieldofresearchGenetics
dc.subject.fieldofresearchZoology
dc.subject.fieldofresearchcode060399
dc.subject.fieldofresearchcode0603
dc.subject.fieldofresearchcode0604
dc.subject.fieldofresearchcode0608
dc.titlePhylogenetic and evolutionary analyses of St. Louis encephalitis virus genomes
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorBaillie, Greg


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