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  • Genome and transcriptome of the porcine whipworm Trichuris suis

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    Author(s)
    Jex, Aaron R
    Nejsum, Peter
    Schwarz, Erich M
    Hu, Li
    Young, Neil D
    Hall, Ross S
    Korhonen, Pasi K
    Liao, Shengguang
    Thamsborg, Stig
    Xia, Jinquan
    Xu, Pengwei
    Wang, Shaowei
    Scheerlinck, Jean-Pierre Y
    Hofmann, Andreas
    Sternberg, Paul W
    Wang, Jun
    Gasser, Robin B
    Griffith University Author(s)
    Hofmann, Andreas
    Year published
    2014
    Metadata
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    Abstract
    Trichuris (whipworm) infects 1 billion people worldwide and causes a disease (trichuriasis) that results in major socioeconomic losses in both humans and pigs. Trichuriasis relates to an inflammation of the large intestine manifested in bloody diarrhea, and chronic disease can cause malnourishment and stunting in children. Paradoxically, Trichuris of pigs has shown substantial promise as a treatment for human autoimmune disorders, including inflammatory bowel disease (IBD) and multiple sclerosis. Here we report whole-genome sequencing at ~140-fold coverage of adult male and female T. suis and ~80-Mb draft assemblies. We ...
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    Trichuris (whipworm) infects 1 billion people worldwide and causes a disease (trichuriasis) that results in major socioeconomic losses in both humans and pigs. Trichuriasis relates to an inflammation of the large intestine manifested in bloody diarrhea, and chronic disease can cause malnourishment and stunting in children. Paradoxically, Trichuris of pigs has shown substantial promise as a treatment for human autoimmune disorders, including inflammatory bowel disease (IBD) and multiple sclerosis. Here we report whole-genome sequencing at ~140-fold coverage of adult male and female T. suis and ~80-Mb draft assemblies. We explore stage-, sex- and tissue-specific transcription of mRNAs and small noncoding RNAs.
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    Journal Title
    Nature Genetics
    Volume
    46
    DOI
    https://doi.org/10.1038/ng.3012
    Copyright Statement
    © The Author(s) 2014. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 (CC BY-NC-SA 3.0 AU) License (http://creativecommons.org/licenses/by-nc-sa/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited. If you alter, transform, or build upon this work, you may distribute the resulting work only under a licence identical to this one.
    Subject
    Biological sciences
    Biomedical and clinical sciences
    Medical parasitology
    Publication URI
    http://hdl.handle.net/10072/62684
    Collection
    • Journal articles

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