Genome and transcriptome of the porcine whipworm Trichuris suis

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Author(s)
Jex, Aaron R
Nejsum, Peter
Schwarz, Erich M
Hu, Li
Young, Neil D
Hall, Ross S
Korhonen, Pasi K
Liao, Shengguang
Thamsborg, Stig
Xia, Jinquan
Xu, Pengwei
Wang, Shaowei
Scheerlinck, Jean-Pierre Y
Hofmann, Andreas
Sternberg, Paul W
Wang, Jun
Gasser, Robin B
Griffith University Author(s)
Year published
2014
Metadata
Show full item recordAbstract
Trichuris (whipworm) infects 1 billion people worldwide and causes a disease (trichuriasis) that results in major socioeconomic losses in both humans and pigs. Trichuriasis relates to an inflammation of the large intestine manifested in bloody diarrhea, and chronic disease can cause malnourishment and stunting in children. Paradoxically, Trichuris of pigs has shown substantial promise as a treatment for human autoimmune disorders, including inflammatory bowel disease (IBD) and multiple sclerosis. Here we report whole-genome sequencing at ~140-fold coverage of adult male and female T. suis and ~80-Mb draft assemblies. We ...
View more >Trichuris (whipworm) infects 1 billion people worldwide and causes a disease (trichuriasis) that results in major socioeconomic losses in both humans and pigs. Trichuriasis relates to an inflammation of the large intestine manifested in bloody diarrhea, and chronic disease can cause malnourishment and stunting in children. Paradoxically, Trichuris of pigs has shown substantial promise as a treatment for human autoimmune disorders, including inflammatory bowel disease (IBD) and multiple sclerosis. Here we report whole-genome sequencing at ~140-fold coverage of adult male and female T. suis and ~80-Mb draft assemblies. We explore stage-, sex- and tissue-specific transcription of mRNAs and small noncoding RNAs.
View less >
View more >Trichuris (whipworm) infects 1 billion people worldwide and causes a disease (trichuriasis) that results in major socioeconomic losses in both humans and pigs. Trichuriasis relates to an inflammation of the large intestine manifested in bloody diarrhea, and chronic disease can cause malnourishment and stunting in children. Paradoxically, Trichuris of pigs has shown substantial promise as a treatment for human autoimmune disorders, including inflammatory bowel disease (IBD) and multiple sclerosis. Here we report whole-genome sequencing at ~140-fold coverage of adult male and female T. suis and ~80-Mb draft assemblies. We explore stage-, sex- and tissue-specific transcription of mRNAs and small noncoding RNAs.
View less >
Journal Title
Nature Genetics
Volume
46
Copyright Statement
© The Author(s) 2014. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 (CC BY-NC-SA 3.0 AU) License (http://creativecommons.org/licenses/by-nc-sa/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited. If you alter, transform, or build upon this work, you may distribute the resulting work only under a licence identical to this one.
Subject
Biological sciences
Biomedical and clinical sciences
Medical parasitology