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dc.contributor.authorKarjalainen, T
dc.contributor.authorWaligora-Dupriet, AJ
dc.contributor.authorCerquetti, M
dc.contributor.authorSpigaglia, P
dc.contributor.authorMaggioni, A
dc.contributor.authorMauri, P
dc.contributor.authorMastrantonio, P
dc.date.accessioned2013-06-29
dc.date.accessioned2017-03-02T00:45:07Z
dc.date.available2015-06-01T23:39:06Z
dc.date.available2017-03-02T00:45:07Z
dc.date.issued2001
dc.identifier.issn0019-9567
dc.identifier.doi10.1128/IAI.69.5.3442-3446.2001
dc.identifier.urihttp://hdl.handle.net/10072/62972
dc.description.abstractThe gene slpA, encoding the S-layer precursor protein in the virulent Clostridium difficile strains C253 and 79–685, was identified. The precursor protein carries a C-terminal highly conserved anchoring domain, similar to the one found in the Cwp66 adhesin (previously characterized in strain 79–685), an SLH domain, and a variable N-terminal domain mediating cell adherence. The genes encoding the S-layer precursor proteins and the Cwp66 adhesin are present in a genetic locus carrying 17 open reading frames, 11 of which encode a similar two-domain architecture, likely to include surface-anchored proteins.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherAmerican Society for Microbiology
dc.publisher.placeUSA
dc.relation.ispartofpagefrom3442
dc.relation.ispartofpageto3446
dc.relation.ispartofissue5
dc.relation.ispartofjournalInfection and Immunity
dc.relation.ispartofvolume69
dc.subject.fieldofresearchBiological sciences
dc.subject.fieldofresearchGenomics
dc.subject.fieldofresearchAgricultural, veterinary and food sciences
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.subject.fieldofresearchcode31
dc.subject.fieldofresearchcode310509
dc.subject.fieldofresearchcode30
dc.subject.fieldofresearchcode32
dc.titleMolecular and Genomic Analysis of Genes Encoding Surface-Anchored Proteins from Clostridium difficile
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codec1x
gro.facultyFaculty of Science, Environment, Engineering and Technology
gro.date.issued2015-06-01T23:39:06Z
gro.hasfulltextNo Full Text
gro.griffith.authorMaggioni, Andrea


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