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  • 1,1,1-trichloro-2,2-bis (p-chlorophenly)-ethane (DDT) and reduces bone mineral density

    Author(s)
    Beard, J
    Marshall, S
    Jong, K
    Newton, R
    Triplett-McBride, T
    Humphries, B
    Bronks, R
    Griffith University Author(s)
    Marshall-Gradisnik, Sonya M.
    Heathcote, Kathy E.
    Year published
    2000
    Metadata
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    Abstract
    The organochlorine pesticide 1,1,1-trichloro-2,2-bis (p-chlorophenyl)-ethane (DDT), is a well-known and widely dispersed "environmental estrogen" (World Health Organization Criteria no. 9; Geneva, Switzerland [1979]). Kelce et al. (Nature, 1995; 375:581-85) recently identified the DDT metabolite, 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE), has also recently been identified as a potent androgen receptor antagonist. The authors examined the relationship between serum levels of DDE and bone mineral density in 68 sedentary women who reported adequate dietary intake of calcium. Reduced bone mineral density was correlated ...
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    The organochlorine pesticide 1,1,1-trichloro-2,2-bis (p-chlorophenyl)-ethane (DDT), is a well-known and widely dispersed "environmental estrogen" (World Health Organization Criteria no. 9; Geneva, Switzerland [1979]). Kelce et al. (Nature, 1995; 375:581-85) recently identified the DDT metabolite, 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE), has also recently been identified as a potent androgen receptor antagonist. The authors examined the relationship between serum levels of DDE and bone mineral density in 68 sedentary women who reported adequate dietary intake of calcium. Reduced bone mineral density was correlated significantly with age (r = -.36, p = .004), as well as with increases in the log of DDE levels in serum (r = -.27, p = .03). The authors also used multiple-regression analysis to examine the influence of other predictor variables on the relationship between log DDE and bone mineral density. The strongest model (p = .002) included log DDE (p = .018), age (p = .002), and years on hormone replacement therapy (p = .10) as predictor variables, and this model afforded prediction of 21% of bone mineral density variation. These results suggest that past community exposures to DDT may be associated with reduced bone mineral density in women.
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    Journal Title
    Archives of Environmental Health
    Volume
    55
    Issue
    3
    DOI
    https://doi.org/10.1080/00039890009603403
    Subject
    Environmental Sciences not elsewhere classified
    Public Health and Health Services
    Publication URI
    http://hdl.handle.net/10072/62973
    Collection
    • Journal articles

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