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  • Henipavirus Neutralising Antibodies in an Isolated Island Population of African Fruit Bats

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    Author(s)
    Peel, Alison J
    Baker, Kate S
    Crameri, Gary
    Barr, Jennifer A
    Hayman, David TS
    Wright, Edward
    Broder, Christopher C
    Fernandez-Loras, Andres
    Fooks, Anthony R
    Wang, Lin-Fa
    Cunningham, Andrew A
    Wood, James LN
    Griffith University Author(s)
    Peel, Alison J.
    Year published
    2012
    Metadata
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    Abstract
    Isolated islands provide valuable opportunities to study the persistence of viruses in wildlife populations, including population size thresholds such as the critical community size. The straw-coloured fruit bat, Eidolon helvum, has been identified as a reservoir for henipaviruses (serological evidence) and Lagos bat virus (LBV; virus isolation and serological evidence) in continental Africa. Here, we sampled from a remote population of E. helvum annobonensis fruit bats on Annobo䮠island in the Gulf of Guinea to investigate whether antibodies to these viruses also exist in this isolated subspecies. Henipavirus serological ...
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    Isolated islands provide valuable opportunities to study the persistence of viruses in wildlife populations, including population size thresholds such as the critical community size. The straw-coloured fruit bat, Eidolon helvum, has been identified as a reservoir for henipaviruses (serological evidence) and Lagos bat virus (LBV; virus isolation and serological evidence) in continental Africa. Here, we sampled from a remote population of E. helvum annobonensis fruit bats on Annobo䮠island in the Gulf of Guinea to investigate whether antibodies to these viruses also exist in this isolated subspecies. Henipavirus serological analyses (Luminex multiplexed binding and inhibition assays, virus neutralisation tests and western blots) and lyssavirus serological analyses (LBV: modified Fluorescent Antibody Virus Neutralisation test, LBV and Mokola virus: lentivirus pseudovirus neutralisation assay) were undertaken on 73 and 70 samples respectively. Given the isolation of fruit bats on Annobo䮠and their lack of connectivity with other populations, it was expected that the population size on the island would be too small to allow persistence of viruses that are thought to cause acute and immunising infections. However, the presence of antibodies against henipaviruses was detected using the Luminex binding assay and confirmed using alternative assays. Neutralising antibodies to LBV were detected in one bat using both assays. We demonstrate clear evidence for exposure of multiple individuals to henipaviruses in this remote population of E. helvum annobonensis fruit bats on Annobo䮠island. The situation is less clear for LBV. Seroprevalences to henipaviruses and LBV in Annobo䮠are notably different to those in E. helvum in continental locations studied using the same sampling techniques and assays. Whilst cross-sectional serological studies in wildlife populations cannot provide details on viral dynamics within populations, valuable information on the presence or absence of viruses may be obtained and utilised for informing future studies.
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    Journal Title
    PloS One
    Volume
    7
    Issue
    1
    DOI
    https://doi.org/10.1371/journal.pone.0030346
    Copyright Statement
    © 2012, Peel et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution License CCAL. (http://www.plos.org/journals/license.html)
    Subject
    Population ecology
    Veterinary epidemiology
    Publication URI
    http://hdl.handle.net/10072/63066
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    • Journal articles

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