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dc.contributor.authorElliott, E
dc.contributor.authorMcIntyre, P
dc.contributor.authorRidley, Greta
dc.contributor.authorMorris, A
dc.contributor.authorMassie, J
dc.contributor.authorMcEniery, J
dc.contributor.authorKnight, G
dc.date.accessioned2014-07-02
dc.date.accessioned2014-09-23T00:14:56Z
dc.date.accessioned2017-03-02T00:34:01Z
dc.date.available2017-03-02T00:34:01Z
dc.date.issued2004
dc.date.modified2014-09-23T00:14:56Z
dc.identifier.issn0891-3668
dc.identifier.urihttp://hdl.handle.net/10072/63068
dc.description.abstractBackground. In Australia in 1999 acellular pertussis vaccine (DTPa) replaced locally manufactured whole cell vaccine given at 2, 4 and 6 months of age with coverage of about 95% by 12 months of age. Few data are available on pertussis hospitalizations or sources of infection in countries exclusively using DTPa. Methods. In 2001 national active monthly surveillance of infant hospitalizations for pertussis was conducted through the Australian Pediatric Surveillance Unit, which surveys all child health specialists monthly. A standard questionnaire was completed for notified cases. Results. There were 140 infants reported (median age at diagnosis, 8 weeks). The rate of hospitalization in indigenous infants was significantly higher than in nonindigenous infants (P < 0.01). Of 97 (69%) infants who had not been vaccinated for pertussis, 63 (65%) were <8 weeks old (before the first scheduled dose of DTPa vaccine). Of 76 infants age ≥8 weeks, only 28 (37%) were appropriately immunized for age. Of 68 coughing contacts whose ages were known, 46 (68%) were adults, usually one of the infant's parents. Of 32 child contacts 16 (50%) were siblings. Four infants <6 weeks old died. Conclusion. Despite universal vaccination with DTPa in Australia, pertussis remains an important cause of hospitalization, morbidity and death in infants, most of whom were too young to be vaccinated or had missed vaccinations. The most common source of infection was a parent. Strategies to improve pertussis control in countries with high DTPa coverage could include adult-formulated booster pertussis vaccines for adolescents and recent parents and/or accelerated pertussis vaccine schedules for infants.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.publisherLippincott Williams & Wilkins
dc.publisher.placeUSA
dc.publisher.urihttp://journals.lww.com/pidj/Abstract/2004/03000/National_study_of_infants_hospitalized_with.14.aspx
dc.relation.ispartofpagefrom246
dc.relation.ispartofpageto252
dc.relation.ispartofissue3
dc.relation.ispartofjournalPaediatric Infectious Disease Journal
dc.relation.ispartofvolume23
dc.subject.fieldofresearchClinical Sciences not elsewhere classified
dc.subject.fieldofresearchPaediatrics and Reproductive Medicine
dc.subject.fieldofresearchPublic Health and Health Services
dc.subject.fieldofresearchcode110399
dc.subject.fieldofresearchcode1114
dc.subject.fieldofresearchcode1117
dc.titleNational study of infants hospitalized with pertussis in the acellular vaccine era.
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codec1x
gro.facultyArts, Education and Law
gro.hasfulltextNo Full Text
gro.griffith.authorRidley, Greta


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