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dc.contributor.authorSubramanian, Sankaren_US
dc.contributor.authorKumar, Sudhiren_US
dc.date.accessioned2012-07-11en_US
dc.date.accessioned2014-09-24T04:58:31Z
dc.date.accessioned2017-03-01T23:54:07Z
dc.date.available2017-03-01T23:54:07Z
dc.date.issued2002en_US
dc.date.modified2014-09-24T04:58:31Z
dc.identifier.issn1091-6490en_US
dc.identifier.doi10.1073/pnas.022629899en_US
dc.identifier.urihttp://hdl.handle.net/10072/63124
dc.description.abstractKnowledge of the rate of point mutation is of fundamental importance, because mutations are a vital source of genetic novelty and a significant cause of human diseases. Currently, mutation rate is thought to vary many fold among genes within a genome and among lineages in mammals. We have conducted a computational analysis of 5,669 genes (17,208 sequences) from species representing major groups of placental mammals to characterize the extent of mutation rate differences among genes in a genome and among diverse mammalian lineages. We find that mutation rate is approximately constant per year and largely similar among genes. Similarity of mutation rates among lineages with vastly different generation lengths and physiological attributes points to a much greater contribution of replication-independent mutational processes to the overall mutation rate. Our results suggest that the average mammalian genome mutation rate is 2.2 109 per base pair per year, which provides further opportunities for estimating species and population divergence times by using molecular clocks.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_US
dc.publisherNational Academy of Sciences USAen_US
dc.publisher.placeUSAen_US
dc.relation.ispartofpagefrom803en_US
dc.relation.ispartofpageto808en_US
dc.relation.ispartofissue2en_US
dc.relation.ispartofjournalProceedings of the National Academy of Sciences (PNAS)en_US
dc.relation.ispartofvolume99en_US
dc.subject.fieldofresearchEvolutionary Biologyen_US
dc.subject.fieldofresearchcode060399en_US
dc.titleMutation rates in mammalian genomesen_US
dc.typeJournal article
dc.type.descriptionJournal Articles (Refereed Article)en_US
dc.type.codec1xen_US
gro.facultyFaculty of Science, Environment, Engineering and Technologyen_US
gro.hasfulltextNo Full Text
gro.griffith.authorSankarasubramanian, Sankar


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