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dc.contributor.authorLakshami, V
dc.contributor.authorKumar, R
dc.contributor.authorGupta, P
dc.contributor.authorVarshney, V
dc.contributor.authorSrivastava, MN
dc.contributor.authorPandey, Manisha
dc.contributor.authorMurthy, PK
dc.contributor.authorMisra-Bhattacharya, Shailja
dc.date.accessioned2012-07-13
dc.date.accessioned2014-09-24T04:59:35Z
dc.date.accessioned2017-03-01T23:54:18Z
dc.date.available2017-03-01T23:54:18Z
dc.date.issued2004
dc.date.modified2014-09-24T04:59:35Z
dc.identifier.issn0932-0113
dc.identifier.doi10.1007/s00436-004-1159-8
dc.identifier.urihttp://hdl.handle.net/10072/63146
dc.description.abstractThe antifilarial activity of the marine red alga Botryocladia leptopoda against rodent and human lymphatic filarial parasites is described. The animal filarial species included Litomosoides sigmodontis and Acanthocheilonema viteae maintained in cotton rats and Mastomys coucha, respectively, while a subperiodic strain of the human lymphatic filarial parasite Brugia malayi was maintained in M. coucha. The crude extract and its hexane fraction brought about a marked reduction in the peripheral microfilarial level in both of the rodent filarial parasites L. sigmodontis and A. viteae. The microfilaricidal effect began slowly from day 8 or 15 after initiation of treatment and increased with time with a very high efficacy at the end of the observation period against both rodent filariids. The microfilaricidal efficacy was, however, not as prominent in the case of B. malayi. The antifilarial activity, which occurred in the hexane fraction, exerted action at a much lower dose. The product killed a significant proportion of A. viteae and L. sigmodontis adult parasites. In the case of B. malayi, although the macrofilaricidal efficacy was much less than that of the rodent parasites, it (hexane fraction) caused sterilization of a significant proportion of the surviving female parasites. The present findings indicate the possibility of developing an adulticidal and female sterilizing agent against filarial parasites from a marine red alga.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.publisherSpringer
dc.publisher.placeUnited States
dc.relation.ispartofpagefrom468
dc.relation.ispartofpageto474
dc.relation.ispartofjournalParasitology Research
dc.relation.ispartofvolume93
dc.subject.fieldofresearchMicrobiology
dc.subject.fieldofresearchInfectious agents
dc.subject.fieldofresearchVeterinary sciences
dc.subject.fieldofresearchMedical microbiology
dc.subject.fieldofresearchcode3107
dc.subject.fieldofresearchcode310702
dc.subject.fieldofresearchcode3009
dc.subject.fieldofresearchcode3207
dc.titleThe antifilarial activity of a marine red alga, Botryocladia leptopoda, against experimental infections with animal and human filariae
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codec1x
gro.facultyFaculty of Science, Environment, Engineering and Technology
gro.hasfulltextNo Full Text
gro.griffith.authorPandey, Manisha


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