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  • The neurodevelopmental hypothesis of schizophrenia: a review of recent developments

    Author(s)
    McGrath, JJ
    Feron, FP
    Burne, THJ
    Mackay-Sim, A
    Eyles, DW
    Griffith University Author(s)
    Mackay-Sim, Alan
    Feron, Francois
    Burne, Thomas HJ.
    McGrath, John J.
    Year published
    2003
    Metadata
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    Abstract
    The neurodevelopmental hypothesis (NDH) of schizophrenia suggests that a disruption of brain development during early life underlies the later emergence of psychosis during adulthood. The aim of this review is to chart the challenges and subsequent refinements to this hypothesis, with particular reference to the static versus progressive nature of the putative neurobiological processes underlying the NDH. A non-systematic literature review was undertaken, with an emphasis on major review papers relevant to the NDH. Weaknesses in the explanatory power of the NDH have led to a new generation of more refined hypotheses in ...
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    The neurodevelopmental hypothesis (NDH) of schizophrenia suggests that a disruption of brain development during early life underlies the later emergence of psychosis during adulthood. The aim of this review is to chart the challenges and subsequent refinements to this hypothesis, with particular reference to the static versus progressive nature of the putative neurobiological processes underlying the NDH. A non-systematic literature review was undertaken, with an emphasis on major review papers relevant to the NDH. Weaknesses in the explanatory power of the NDH have led to a new generation of more refined hypotheses in recent years. In particular, recent versions of the hypothesis have incorporated evidence from structural neuroimaging which suggests changes in brain volumes after the onset of schizophrenia. More detailed models that incorporate progressive neurobiological processes have replaced early versions of the NDH, which were based on a 'static encephalopathy'. In addition, recent models have suggested that two or more 'hits' are required over the lifespan rather than only one early-life event. Animal models are providing important insights into the sequelae of disturbed early brain development. The NDH has provided great impetus to the schizophrenia research community. Recent versions of the hypothesis have encouraged more focused and testable hypotheses.
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    Journal Title
    Annals of Medicine
    Volume
    35
    Issue
    2
    DOI
    https://doi.org/10.1080/07853890310010005
    Subject
    Medical and Health Sciences
    Publication URI
    http://hdl.handle.net/10072/6329
    Collection
    • Journal articles

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