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  • Nervous translation, do you get the message? A review of mRNPs, mRNA–protein interactions and translational control within cells of the nervous system

    Author(s)
    Smith, Ross
    Rathod, Reena Jagdish
    Rajkumar, Shalini
    Kennedy, Derek
    Griffith University Author(s)
    Kennedy, Derek D.
    Year published
    2014
    Metadata
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    Abstract
    In neurons, translation of a message RNA can occur metres away from its transcriptional origin and in normal cells this is orchestrated with perfection. The life of an mRNA will see it pass through multiple steps of processing in the nucleus and the cytoplasm before it reaches its final destination. Processing of mRNA is determined by a myriad of RNA-binding proteins in multi-protein complexes called messenger ribonucleoproteins; however, incorrect processing and delivery of mRNA can cause several human neurological disorders. This review takes us through the life of mRNA from the nucleus to its point of translation in the ...
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    In neurons, translation of a message RNA can occur metres away from its transcriptional origin and in normal cells this is orchestrated with perfection. The life of an mRNA will see it pass through multiple steps of processing in the nucleus and the cytoplasm before it reaches its final destination. Processing of mRNA is determined by a myriad of RNA-binding proteins in multi-protein complexes called messenger ribonucleoproteins; however, incorrect processing and delivery of mRNA can cause several human neurological disorders. This review takes us through the life of mRNA from the nucleus to its point of translation in the cytoplasm. The review looks at the various cis and trans factors that act on the mRNA and discusses their roles in different cells of the nervous system and human disorders.
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    Journal Title
    Cellular and Molecular Life Sciences
    DOI
    https://doi.org/10.1007/s00018-014-1660-x
    Subject
    Biochemistry and cell biology
    Zoology
    Clinical sciences
    Cellular nervous system
    Publication URI
    http://hdl.handle.net/10072/63366
    Collection
    • Journal articles

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