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  • Assessing inherited and individual risk factors for dental caries

    Author(s)
    Fernando, Surani
    Speicher, David
    Scuffham, Paul Anthony
    Lea, Rod
    Bakr, Mahmoud
    Johnson, Newell Walter
    Griffith University Author(s)
    Speicher, David J.
    Johnson, Newell W.
    Scuffham, Paul A.
    Bakr, Mahmoud
    Fernando, Surani
    Year published
    2014
    Metadata
    Show full item record
    Abstract
    Background. Oral diseases are amongst the costliest in Australia. Oral Health expenditure is the sixth highest health cost and accounts for 7% of total allocated health expenditure ($3.4 billion). Decreased productivity, days lost at work and school increase the community burden. According to the Australian Institute of Health and Welfare 2011, ~49% of Australian children aged 6 had caries experience in their deciduous teeth and this is rising. The aetiology of dental caries involves a complex interplay of individual, behavioural, social, economic, political and environmental conditions, and there is renewed interest in ...
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    Background. Oral diseases are amongst the costliest in Australia. Oral Health expenditure is the sixth highest health cost and accounts for 7% of total allocated health expenditure ($3.4 billion). Decreased productivity, days lost at work and school increase the community burden. According to the Australian Institute of Health and Welfare 2011, ~49% of Australian children aged 6 had caries experience in their deciduous teeth and this is rising. The aetiology of dental caries involves a complex interplay of individual, behavioural, social, economic, political and environmental conditions, and there is renewed interest in genetic predisposition. The ongoing Griffith University Birth Cohort Study provides a valuable opportunity to investigate genetic and acquired risk factors by examination of enrolled children and their parents. Objectives. To quantify risk factors for dental caries in a population of Queensland children: social; environmental; behavioural; physiological and inherited. Methods. The Oral Health Sub-study began in November 2012 by examining mothers and their 6 year old children, these being the first (2006) birth cohort: examination of subsequent years is progressing. Detailed questionnaire data of families is available and new primary data on knowledge, attitudes and practices towards oral health are gathered. Height, waist circumference and stride length of mother and child are measured. They are weighed with an electronic Bio-Impedance balance, thereby recording body fat, body water and body mass index. Caries is scored using the International Caries Detection and Scoring system (ICDAS II, 2007). Saliva is collected for physiological measures and DNA extracted for genetic studies. A pilot of the latter concentrates on potential epigenetic markers of risk based on methylation sequencing on the Roche SeqCap Capture platform. Results. Results of the first 52 mother/child dyads shows significant correlations between the child's caries experience and the mother's level of salivary Mutans Streptocci (p=0.01), mothers' caries experience (p=0.01) and mothers' BMI (p=0.05). Conclusion. The correlations found so far between maternal and child oral health indicators and disease experience give confidence in the protocol, justifying the search for genetic influences.
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    Conference Title
    Assessing inherited and individual risk factors for dental caries
    Publisher URI
    https://iadr.abstractarchives.com/abstract/anz14-193571/assessing-inherited-and-individual-risk-factors-for-dental-caries
    Copyright Statement
    Self-archiving of the author-manuscript version is not yet supported by this Publisher. Please refer to the conference link for access to the definitive, published version or contact the authors for more information.
    Subject
    Paedodontics
    Publication URI
    http://hdl.handle.net/10072/63526
    Collection
    • Conference outputs

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