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dc.contributor.authorKorsgren, M
dc.contributor.authorErjefalt, JS
dc.contributor.authorHinterholzl, J
dc.contributor.authorFischer-Colbrie, R
dc.contributor.authorEmanuelsson, CA
dc.contributor.authorAndersson, M
dc.contributor.authorPersson, CGA
dc.contributor.authorMackay-Sim, A
dc.contributor.authorSundler, F
dc.contributor.authorGreiff, L
dc.contributor.editorAlan R Leff, Christina Shepherd
dc.description.abstractSecretoneurin is a neuropeptide potentially involved in migration of eosinophils, monocytes, and dendritic cells. Whether secretoneurin is present in the human airway mucosa and whether it is released at ongoing allergic airway inflammation is currently unknown. In patients with allergic rhinitis, we have explored the occurrence of secretoneurin in nasal mucosal biopsies and lavage fluids before and during natural allergen exposure. Immunohistochemical analysis revealed an abundance of nerves displaying secretoneurin immunoreactivity, which were distributed predominantly around blood vessels and submucosal glands. A majority of nerve fibers containing vesicular acetylcholine transporter, tyrosine hydroxylase, calcitonin gene-related peptide, and vasoactive intestinal peptide were also secretoneurin-immunoreactive, indicating a localization of secretoneurin in cholinergic, adrenergic, and sensory nerves. Lavage fluid levels of secretoneurin were increased at allergen exposure (p < 0.01-0.05). Levels of secretoneurin did not correlate with eosinophil cationic protein ({rho} = 0.1, p = 0.7). We conclude that secretoneurin has a widespread occurrence in nasal mucosal nerves of patients with seasonal allergic rhinitis and that increased nasal lavage fluid levels of secretoneurin may characterize ongoing allergen exposure. These data favor a role of secretoneurin in the local traffic of immune cells in human airway mucosa.
dc.publisherAmerican Lung Association
dc.publisher.placeNew York
dc.relation.ispartofjournalAmerican Journal of Respiratory and Critical Care Medicine
dc.subject.fieldofresearchMedical and Health Sciences
dc.titleNeural Expression and Increased Lavage Fluid Levels of Secretoneurin in Seasonal Allergic Rhinitis
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.rights.copyrightSelf-archiving of the author-manuscript version is not yet supported by this journal. Please refer to the journal link for access to the definitive, published version or contact the authors for more information.
gro.hasfulltextNo Full Text
gro.griffith.authorMackay-Sim, Alan

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