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dc.contributor.authorBreugelmans, Bert
dc.contributor.authorJex, Aaron R
dc.contributor.authorKorhonen, Pasi K
dc.contributor.authorMangiola, Stefano
dc.contributor.authorYoung, Neil D
dc.contributor.authorSternberg, Paul W
dc.contributor.authorBoag, Peter R
dc.contributor.authorHofmann, Andreas
dc.contributor.authorGasser, Robin B
dc.date.accessioned2017-05-03T15:19:23Z
dc.date.available2017-05-03T15:19:23Z
dc.date.issued2014
dc.identifier.issn0020-7519
dc.identifier.doi10.1016/j.ijpara.2014.06.005
dc.identifier.urihttp://hdl.handle.net/10072/63606
dc.description.abstractDespite right open reading frame kinases (RIOKs) being essential for life, their functions, substrates and cellular pathways remain enigmatic. In the present study, gene structures were characterised for 26 RIOKs from draft genomes of parasitic and free-living nematodes. RNA-seq transcription profiles of riok genes were investigated for selected parasitic nematodes and showed that these kinases are transcribed in developmental stages that infect their mammalian host. Three-dimensional structural models of Caenorhabditis elegans RIOKs were predicted, and elucidated functional domains and conserved regions in nematode homologs. These findings provide prospects for functional studies of riok genes in C. elegans, and an opportunity for the design and validation of nematode-specific inhibitors of these enzymes in socioeconomic parasitic worms.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent2300081 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeUnited Kingdom
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom1
dc.relation.ispartofpageto10
dc.relation.ispartofjournalInternational Journal for Parasitology
dc.rights.retentionY
dc.subject.fieldofresearchMicrobiology
dc.subject.fieldofresearchZoology
dc.subject.fieldofresearchVeterinary sciences
dc.subject.fieldofresearchMedical parasitology
dc.subject.fieldofresearchcode3107
dc.subject.fieldofresearchcode3109
dc.subject.fieldofresearchcode3009
dc.subject.fieldofresearchcode320704
dc.titleBioinformatic exploration of RIO protein kinases of parasitic and free-living nematodes
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.rights.copyright© 2014 Elsevier Inc. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
gro.date.issued2015-01-20T01:06:02Z
gro.hasfulltextFull Text
gro.griffith.authorHofmann, Andreas


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