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dc.contributor.authorWang, Aifei
dc.contributor.authorGuo, Mingyi
dc.contributor.authorWang, Nan
dc.contributor.authorZhao, Jianyun
dc.contributor.authorQi, Wenxiu
dc.contributor.authorMuhammad, Faheem
dc.contributor.authorChen, Liang
dc.contributor.authorGuo, Yingjie
dc.contributor.authorNam-Trung, Nguyen
dc.contributor.authorZhu, Guangshan
dc.date.accessioned2018-07-23T04:00:49Z
dc.date.available2018-07-23T04:00:49Z
dc.date.issued2014
dc.identifier.issn2040-3364
dc.identifier.doi10.1039/C3NR05687B
dc.identifier.urihttp://hdl.handle.net/10072/63695
dc.description.abstractManganese oxide (Mn3O4) nanoparticles have recently emerged as a promising T1 contrast agent. In this study, for the first time, we demonstrated an interaction of Mn3O4 with a biological system, and found redox sensitive behavior of these paramagnetic nanoparticles in intracellular reducing environment. Inspired by these findings, we for the first time used this interaction for some therapeutic advantages and designed a versatile mesoporous silica based nanotheranostic system to realize redox-activated enhanced magnetic resonance imaging and responsive anticancer drug delivery. Contrary to previous reports, we firstly prepared high quality amine terminated hydrophilic Mn3O4 nanolids, without using multistep ligand exchange strategies. The resulting water stable and small-sized Mn3O4 nanolids were subsequently used as nanolids to cap drug loaded nanochannels of a porous carrier. Exposure to highly prevalent intracellular reducing environment resulted in the steady-state dissolution of these nanolids and attained an intelligent drug release. Furthermore, the redox receptive dissolution of paramagnetic Mn3O4 nanolids into Mn2+ in turn increases the T1 signal to twofold, providing an added opportunity to even track the feedback of therapy. This study, in addition to simultaneously realizing drug delivery and imaging, also provides a new insight into the fate and interaction of manganese oxide nanoparticles with components of biological systems.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherRSC
dc.publisher.placeUnited Kingdom
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom5270
dc.relation.ispartofpageto5278
dc.relation.ispartofissue10
dc.relation.ispartofjournalNanoscale
dc.relation.ispartofvolume6
dc.rights.retentionY
dc.subject.fieldofresearchPhysical sciences
dc.subject.fieldofresearchChemical sciences
dc.subject.fieldofresearchNanomaterials
dc.subject.fieldofresearchNanomedicine
dc.subject.fieldofresearchcode51
dc.subject.fieldofresearchcode34
dc.subject.fieldofresearchcode401807
dc.subject.fieldofresearchcode320604
dc.titleRedox-mediated dissolution of paramagnetic nanolids to achieve a smart theranostic system
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dc.description.versionAccepted Manuscript (AM)
gro.rights.copyright© 2014 Royal Society of Chemistry. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal website for access to the definitive, published version.
gro.hasfulltextFull Text
gro.griffith.authorNguyen, Nam-Trung


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