dc.contributor.author | Zhang, Jun | |
dc.contributor.author | Yan, Sheng | |
dc.contributor.author | Li, Weihua | |
dc.contributor.author | Alici, Gursel | |
dc.contributor.author | Nam-Trung, Nguyen | |
dc.date.accessioned | 2017-05-03T16:14:52Z | |
dc.date.available | 2017-05-03T16:14:52Z | |
dc.date.issued | 2014 | |
dc.identifier.issn | 2046-2069 | |
dc.identifier.doi | 10.1039/C4RA06513A | |
dc.identifier.uri | http://hdl.handle.net/10072/63767 | |
dc.description.abstract | In this paper, we report the development of a simple inertial microfluidic device with a serpentine channel for efficiently separating blood cells from plasma. The working mechanism of this device relies on the two-sided secondary flow aided inertial focusing of particles in a serpentine channel. Specifically, blood cells were focused along two sides of the channel, while the blood plasma was collected at the cell-free region within the channel centre. The device was tested with diluted (1/20) whole blood. A relatively high flow rate of 350 嬠min-1 with a purity of [similar]99.75% was achieved in a single process. A further improvement to 99.95% purity was obtained after a second process. Parallelization with eight parallel serpentine channels achieved a high flow rate of 2.8 ml min-1 and a massive throughput of 7 נ108 cells per min. Our device could be easily integrated with other sample preparation processes or detection units to form a sample-to-answer lab-on-a-chip system. | |
dc.description.peerreviewed | Yes | |
dc.description.publicationstatus | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | R S C Publications | |
dc.publisher.place | United Kingdom | |
dc.relation.ispartofstudentpublication | N | |
dc.relation.ispartofpagefrom | 33149 | |
dc.relation.ispartofpageto | 33159 | |
dc.relation.ispartofjournal | RSC Advances | |
dc.relation.ispartofvolume | 4 | |
dc.rights.retention | Y | |
dc.subject.fieldofresearch | Chemical sciences | |
dc.subject.fieldofresearch | Biomedical instrumentation | |
dc.subject.fieldofresearchcode | 34 | |
dc.subject.fieldofresearchcode | 400305 | |
dc.title | High throughput extraction of plasma using a secondary flow-aided inertial microfluidic device | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
dc.description.version | Accepted Manuscript (AM) | |
gro.rights.copyright | © 2014 Royal Society of Chemistry. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal website for access to the definitive, published version. | |
gro.hasfulltext | Full Text | |
gro.griffith.author | Nguyen, Nam-Trung | |
gro.griffith.author | Zhang, Jun | |