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dc.contributor.authorZhang, Jun
dc.contributor.authorYan, Sheng
dc.contributor.authorLi, Weihua
dc.contributor.authorAlici, Gursel
dc.contributor.authorNam-Trung, Nguyen
dc.date.accessioned2017-05-03T16:14:52Z
dc.date.available2017-05-03T16:14:52Z
dc.date.issued2014
dc.identifier.issn2046-2069
dc.identifier.doi10.1039/C4RA06513A
dc.identifier.urihttp://hdl.handle.net/10072/63767
dc.description.abstractIn this paper, we report the development of a simple inertial microfluidic device with a serpentine channel for efficiently separating blood cells from plasma. The working mechanism of this device relies on the two-sided secondary flow aided inertial focusing of particles in a serpentine channel. Specifically, blood cells were focused along two sides of the channel, while the blood plasma was collected at the cell-free region within the channel centre. The device was tested with diluted (1/20) whole blood. A relatively high flow rate of 350 嬠min-1 with a purity of [similar]99.75% was achieved in a single process. A further improvement to 99.95% purity was obtained after a second process. Parallelization with eight parallel serpentine channels achieved a high flow rate of 2.8 ml min-1 and a massive throughput of 7 נ108 cells per min. Our device could be easily integrated with other sample preparation processes or detection units to form a sample-to-answer lab-on-a-chip system.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherR S C Publications
dc.publisher.placeUnited Kingdom
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom33149
dc.relation.ispartofpageto33159
dc.relation.ispartofjournalRSC Advances
dc.relation.ispartofvolume4
dc.rights.retentionY
dc.subject.fieldofresearchChemical sciences
dc.subject.fieldofresearchBiomedical instrumentation
dc.subject.fieldofresearchcode34
dc.subject.fieldofresearchcode400305
dc.titleHigh throughput extraction of plasma using a secondary flow-aided inertial microfluidic device
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dc.description.versionAccepted Manuscript (AM)
gro.rights.copyright© 2014 Royal Society of Chemistry. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal website for access to the definitive, published version.
gro.hasfulltextFull Text
gro.griffith.authorNguyen, Nam-Trung
gro.griffith.authorZhang, Jun


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