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dc.contributor.authorZhang, Jun
dc.contributor.authorYan, Sheng
dc.contributor.authorSluyter, Ronald
dc.contributor.authorLi, Weihua
dc.contributor.authorAlici, Gursel
dc.contributor.authorNam-Trung, Nguyen
dc.date.accessioned2017-05-03T16:14:50Z
dc.date.available2017-05-03T16:14:50Z
dc.date.issued2014
dc.identifier.issn2045-2322
dc.identifier.doi10.1038/srep04527
dc.identifier.urihttp://hdl.handle.net/10072/63784
dc.description.abstractThis paper presents an inertial microfluidic device with a simple serpentine micro-channel to continuously separate particles with high performance. Separation of micro/nano-particles has a variety of potential applications in biomedicine and industry. Among the existing separation technologies, a label-free technique without the use of antibody affinity, filter or centrifugation is highly desired to ensure minimal damage and alteration to the cells. Inertial microfluidics utilising hydrodynamic forces to separate particles is one of the most suitable label-free technologies with a high throughput. Our separation concept relies on size-based differential equilibrium positions of the particles perpendicular to the flow. Highly efficient separation is demonstrated with particles of different sizes. The results indicate that the proposed device has an integrative advantage to the existing microfluidic separation techniques, taking accounts of purity, efficiency, parallelizability, footprint, throughput and resolution. Our device is expected to be a good alternative to conventional separation methods for sample preparation and clinical diagnosis.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent3530307 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherNature Publishing Group
dc.publisher.placeUnited Kingdom
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom4527-1
dc.relation.ispartofpageto4527-9
dc.relation.ispartofjournalScientific Reports
dc.relation.ispartofvolume4
dc.rights.retentionY
dc.subject.fieldofresearchBiomedical Instrumentation
dc.subject.fieldofresearchFluid Physics
dc.subject.fieldofresearchcode090303
dc.subject.fieldofresearchcode020303
dc.titleInertial particle separation by differential equilibrium positions in a symmetrical serpentine micro-channel
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by-nc-nd/3.0/
gro.rights.copyright© The Author(s) 2014. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported (CC BY-NC-ND 3.0) License (http://creativecommons.org/licenses/by-nc-nd/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited. You may not alter, transform, or build upon this work.
gro.hasfulltextFull Text
gro.griffith.authorNguyen, Nam-Trung
gro.griffith.authorZhang, Jun


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