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  • Crucial roles for olfactory ensheathing cells and olfactory mucosal cells in the repair of damaged neural tracts

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    Author(s)
    Ekberg, Jenny AK
    St John, James A
    Griffith University Author(s)
    St John, James A.
    Ekberg, Jenny A.
    Year published
    2014
    Metadata
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    Abstract
    Olfactory ensheathing cells, the glial cells of the olfactory nervous system, exhibit unique growth-promoting and migratory properties that make them interesting candidates for cell therapies targeting neuronal injuries such as spinal cord injury. Transplantation of olfactory cells is feasible and safe in humans; however, functional outcomes are highly variable with some studies showing dramatic improvements and some no improvements at all. We propose that the reason for this is that the identity and purity of the cells is different in each individual study. We have shown that olfactory ensheathing cells are not a uniform ...
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    Olfactory ensheathing cells, the glial cells of the olfactory nervous system, exhibit unique growth-promoting and migratory properties that make them interesting candidates for cell therapies targeting neuronal injuries such as spinal cord injury. Transplantation of olfactory cells is feasible and safe in humans; however, functional outcomes are highly variable with some studies showing dramatic improvements and some no improvements at all. We propose that the reason for this is that the identity and purity of the cells is different in each individual study. We have shown that olfactory ensheathing cells are not a uniform cell population and that individual subpopulations of OECs are present in different regions of the olfactory nervous system, with strikingly different behaviors. Furthermore, the presence of fibroblasts and other cell types in the transplant can dramatically alter the behavior of the transplanted glial cells. Thus, a thorough characterization of the differences between olfactory ensheathing cell subpopulations and how the behavior of these cells is affected by the presence of other cell types is highly warranted.
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    Journal Title
    The Anatomical Record
    Volume
    297
    DOI
    https://doi.org/10.1002/ar.22803
    Copyright Statement
    © 2014 Wiley Periodicals, Inc.. This is the pre-peer reviewed version of the following article: Crucial roles for olfactory ensheathing cells and olfactory mucosal cells in the repair of damaged neural tracts, The Anatomical Record, Vol. 297, 2014, pp. 121-1283, which has been published in final form at http://dx.doi.org/10.1002/ar.22803.
    Subject
    Biological sciences
    Biomedical and clinical sciences
    Central nervous system
    Peripheral nervous system
    Publication URI
    http://hdl.handle.net/10072/63829
    Collection
    • Journal articles

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