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dc.contributor.authorEkberg, Jenny AK
dc.contributor.authorSt John, James A
dc.date.accessioned2017-05-03T15:27:04Z
dc.date.available2017-05-03T15:27:04Z
dc.date.issued2014
dc.identifier.issn1932-8486
dc.identifier.doi10.1002/ar.22803
dc.identifier.urihttp://hdl.handle.net/10072/63829
dc.description.abstractOlfactory ensheathing cells, the glial cells of the olfactory nervous system, exhibit unique growth-promoting and migratory properties that make them interesting candidates for cell therapies targeting neuronal injuries such as spinal cord injury. Transplantation of olfactory cells is feasible and safe in humans; however, functional outcomes are highly variable with some studies showing dramatic improvements and some no improvements at all. We propose that the reason for this is that the identity and purity of the cells is different in each individual study. We have shown that olfactory ensheathing cells are not a uniform cell population and that individual subpopulations of OECs are present in different regions of the olfactory nervous system, with strikingly different behaviors. Furthermore, the presence of fibroblasts and other cell types in the transplant can dramatically alter the behavior of the transplanted glial cells. Thus, a thorough characterization of the differences between olfactory ensheathing cell subpopulations and how the behavior of these cells is affected by the presence of other cell types is highly warranted.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent152454 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherWiley
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom121
dc.relation.ispartofpageto128
dc.relation.ispartofjournalThe Anatomical Record
dc.relation.ispartofvolume297
dc.rights.retentionY
dc.subject.fieldofresearchBiological sciences
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.subject.fieldofresearchCentral nervous system
dc.subject.fieldofresearchPeripheral nervous system
dc.subject.fieldofresearchcode31
dc.subject.fieldofresearchcode32
dc.subject.fieldofresearchcode320903
dc.subject.fieldofresearchcode320906
dc.titleCrucial roles for olfactory ensheathing cells and olfactory mucosal cells in the repair of damaged neural tracts
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.rights.copyright© 2014 Wiley Periodicals, Inc.. This is the pre-peer reviewed version of the following article: Crucial roles for olfactory ensheathing cells and olfactory mucosal cells in the repair of damaged neural tracts, The Anatomical Record, Vol. 297, 2014, pp. 121-1283, which has been published in final form at http://dx.doi.org/10.1002/ar.22803.
gro.date.issued2014-11-17T21:53:45Z
gro.hasfulltextFull Text
gro.griffith.authorSt John, James A.
gro.griffith.authorEkberg, Jenny A.


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