The adapter proteins of TLRs, TRIF and MYD88, are upregulated in depressed individuals
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Background and aims. TRIF and MYD88 are intracellular adaptor proteins for TLR signaling, and altered expression of these molecules can lead to defective or unregulated immune responses. Furthermore, previous studies revealed that depression may alter immune responses, but its mechanisms of action are unclear yet. Th ere is a possibility that immunity and depression are linked through molecules such as TRIF and MYD88, thus, the aim of this study was to evaluate the mRNA levels of TRIF and MYD88 in the PBMCs isolated from depressed medical students. Material and methods. Th e current study examined 38 depressed medical students studying in Iran and 43 healthy students from the same cohort as a control group. Th e mRNA levels of TRIF and MYD88 were examined in parallel with a housekeeping gene using real-time PCR. Results. Our results demonstrated that expression of TRIF and MYD88 were signifi cantly elevated in PBMCs isolated from depressed patients when compared to healthy subjects. Conclusions. Based on the current results, it seems that chronic infl ammation in depressed patients correlates to the over expression of TRIF and MYD88 genes. Our results show a possible link between the reported increases of chronic infl ammation in depressed individuals with unbalanced expression of genes that regulate immunity.
International Journal of Psychiatry in Clinical Practice
Neurosciences not elsewhere classified