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  • Chikungunya Virus: Emerging Targets and New Opportunities for Medicinal Chemistry

    Author(s)
    Rashad, Adel A
    Mahalingam, Suresh
    Keller, Paul A
    Griffith University Author(s)
    Mahalingam, Suresh
    Year published
    2014
    Metadata
    Show full item record
    Abstract
    Chikungunya virus is an emerging arbovirus that is widespread in tropical regions and is spreading quickly to temperate climates with recent epidemics in Africa and Asia and documented outbreaks in Europe and the Americas. It is having an increasingly major impact on humankind, with potentially life-threatening and debilitating arthritis. There is no treatment available, and only in the past 24 months have lead compounds for development as potential therapeutics been reported. This Perspective discusses the chikungunya virus as a significant, new emerging topic for medicinal chemistry, highlighting the key viral target ...
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    Chikungunya virus is an emerging arbovirus that is widespread in tropical regions and is spreading quickly to temperate climates with recent epidemics in Africa and Asia and documented outbreaks in Europe and the Americas. It is having an increasingly major impact on humankind, with potentially life-threatening and debilitating arthritis. There is no treatment available, and only in the past 24 months have lead compounds for development as potential therapeutics been reported. This Perspective discusses the chikungunya virus as a significant, new emerging topic for medicinal chemistry, highlighting the key viral target proteins and their molecular functions that can be used in drug design, as well as the most important ongoing developments for anti-chikungunya virus research. It represents a complete picture of the current medicinal chemistry of chikungunya, supporting the development of chemotherapeutics through drug discovery and design targeting this virus.
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    Journal Title
    Journal of Medicinal Chemistry
    Volume
    57
    Issue
    4
    DOI
    https://doi.org/10.1021/jm400460d
    Copyright Statement
    Self-archiving of the author-manuscript version is not yet supported by this journal. Please refer to the journal link for access to the definitive, published version or contact the authors for more information.
    Subject
    Medicinal and biomolecular chemistry
    Organic chemistry
    Virology
    Pharmacology and pharmaceutical sciences
    Publication URI
    http://hdl.handle.net/10072/64072
    Collection
    • Journal articles

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