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dc.contributor.authorKhokhar, Shahanen_US
dc.contributor.authorFeng, Yunen_US
dc.contributor.authorCampitelli, Marcen_US
dc.contributor.authorG. Ekin, Merricken_US
dc.contributor.authorHooper, Johnen_US
dc.contributor.authorBeattie, Karrenen_US
dc.contributor.authorC. Sadowski, Martinen_US
dc.contributor.authorC. Nelson, Colleenen_US
dc.contributor.authorDavis, Rohanen_US
dc.date.accessioned2017-05-03T12:46:50Z
dc.date.available2017-05-03T12:46:50Z
dc.date.issued2014en_US
dc.identifier.issn0960894Xen_US
dc.identifier.doi10.1016/j.bmcl.2014.05.104en_US
dc.identifier.urihttp://hdl.handle.net/10072/64083
dc.description.abstractMass-guided fractionation of the MeOH extract from a specimen of the Australian marine sponge Hyrtios sp. resulted in the isolation of two new tryptophan alkaloids, 6-oxofascaplysin (2), and secofascaplysic acid (3), in addition to the known metabolites fascaplysin (1) and reticulatate (4). The structures of all molecules were determined following NMR and MS data analysis. Structural ambiguities in 2 were addressed through comparison of experimental and DFT-generated theoretical NMR spectral values. Compounds 1-4 were evaluated for their cytotoxicity against a prostate cancer cell line (LNCaP) and were shown to display IC50 values ranging from 0.54 to 44.9 lM.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_US
dc.languageEnglishen_US
dc.publisherElsevieren_US
dc.publisher.placeUnited Kingdomen_US
dc.relation.ispartofstudentpublicationNen_US
dc.relation.ispartofpagefrom3329en_US
dc.relation.ispartofpageto3332en_US
dc.relation.ispartofissue15en_US
dc.relation.ispartofjournalBioorganic & Medicinal Chemistry Lettersen_US
dc.relation.ispartofvolume24en_US
dc.rights.retentionNen_US
dc.subject.fieldofresearchBiologically Active Moleculesen_US
dc.subject.fieldofresearchcode030401en_US
dc.titleIsolation, structure determination and cytotoxicity studies of tryptophan alkaloids from an Australian marine sponge Hyrtios sp.en_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.facultyGriffith Sciences, Griffith Institute for Drug Discoveryen_US
gro.hasfulltextNo Full Text


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