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dc.contributor.authorKhokhar, Shahan
dc.contributor.authorFeng, Yunjiang
dc.contributor.authorCampitelli, Marc R
dc.contributor.authorEkins, Merrick G
dc.contributor.authorHooper, John NA
dc.contributor.authorBeattie, Karren D
dc.contributor.authorSadowski, Martin C
dc.contributor.authorNelson, Colleen C
dc.contributor.authorDavis, Rohan A
dc.date.accessioned2017-05-03T12:46:50Z
dc.date.available2017-05-03T12:46:50Z
dc.date.issued2014
dc.identifier.issn0960-894X
dc.identifier.doi10.1016/j.bmcl.2014.05.104
dc.identifier.urihttp://hdl.handle.net/10072/64083
dc.description.abstractMass-guided fractionation of the MeOH extract from a specimen of the Australian marine sponge Hyrtios sp. resulted in the isolation of two new tryptophan alkaloids, 6-oxofascaplysin (2), and secofascaplysic acid (3), in addition to the known metabolites fascaplysin (1) and reticulatate (4). The structures of all molecules were determined following NMR and MS data analysis. Structural ambiguities in 2 were addressed through comparison of experimental and DFT-generated theoretical NMR spectral values. Compounds 1-4 were evaluated for their cytotoxicity against a prostate cancer cell line (LNCaP) and were shown to display IC50 values ranging from 0.54 to 44.9 lM.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.publisherElsevier
dc.publisher.placeUnited Kingdom
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom3329
dc.relation.ispartofpageto3332
dc.relation.ispartofissue15
dc.relation.ispartofjournalBioorganic & Medicinal Chemistry Letters
dc.relation.ispartofvolume24
dc.rights.retentionN
dc.subject.fieldofresearchBiologically Active Molecules
dc.subject.fieldofresearchMedicinal and Biomolecular Chemistry
dc.subject.fieldofresearchPharmacology and Pharmaceutical Sciences
dc.subject.fieldofresearchOrganic Chemistry
dc.subject.fieldofresearchcode030401
dc.subject.fieldofresearchcode0304
dc.subject.fieldofresearchcode1115
dc.subject.fieldofresearchcode0305
dc.titleIsolation, structure determination and cytotoxicity studies of tryptophan alkaloids from an Australian marine sponge Hyrtios sp.
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Sciences, Griffith Institute for Drug Discovery
gro.hasfulltextNo Full Text
gro.griffith.authorDavis, Rohan A.
gro.griffith.authorHooper, John N.
gro.griffith.authorCampitelli, Marc R.
gro.griffith.authorFeng, Yun J.
gro.griffith.authorMitchell, Karren D.
gro.griffith.authorKhokhar, Shahan


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