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dc.contributor.authorFox, Kate L
dc.contributor.authorAtack, John M
dc.contributor.authorSrikhanta, Yogitha N
dc.contributor.authorEckert, Anja
dc.contributor.authorNovotny, Laura A
dc.contributor.authorBakaletz, Lauren O
dc.contributor.authorJennings, Michael P
dc.date.accessioned2017-05-03T16:10:04Z
dc.date.available2017-05-03T16:10:04Z
dc.date.issued2014
dc.identifier.issn1932-6203
dc.identifier.doi10.1371/journal.pone.0090505
dc.identifier.urihttp://hdl.handle.net/10072/64087
dc.description.abstractSurface structures in Haemophilus influenzae are subject to rapid ON/OFF switching of expression, a process termed phase variation. We analyse tetranucleotide repeats controlling phase variation in lipo-oligosaccharide (LOS) genes of H. influenzae in paired isolates from both the nasopharynx and middle ears of paediatric patients with chronic or recurrent otitis media. A change in expression of at least one of the seven phase variable LOS biosynthesis genes was seen in 12 of the 21 strain pairs. Several strains showed switching of expression in multiple LOS genes, consistent with a key role for phase variable LOS biosynthetic genes in human infection.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent369866 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherPublic Library of Science
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrome90505-1
dc.relation.ispartofpagetoe90505-6
dc.relation.ispartofissue2
dc.relation.ispartofjournalPL o S One
dc.relation.ispartofvolume9
dc.rights.retentionY
dc.subject.fieldofresearchBacteriology
dc.subject.fieldofresearchcode310701
dc.titleSelection for Phase Variation of LOS Biosynthetic Genes Frequently Occurs in Progression of Non-Typeable Haemophilus influenzae Infection from the Nasopharynx to the Middle Ear of Human Patients
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://www.plos.org/journals/license.html
gro.rights.copyright© 2014 Fox et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution License CCAL. (http://www.plos.org/journals/license.html)
gro.hasfulltextFull Text
gro.griffith.authorJennings, Michael P.
gro.griffith.authorAtack, John M.


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