Show simple item record

dc.contributor.authorSirdaarta, Joseph
dc.contributor.authorDesegaulx, M.
dc.contributor.authorRayan, P.
dc.contributor.authorMcDonnell, Ann
dc.contributor.authorCock, Ian Edwin
dc.date.accessioned2014-10-31
dc.date.accessioned2014-11-10T03:19:22Z
dc.date.accessioned2017-03-02T00:41:01Z
dc.date.available2014-11-10T03:19:22Z
dc.date.available2017-03-02T00:41:01Z
dc.date.issued2014
dc.identifier.urihttp://hdl.handle.net/10072/64457
dc.description.abstractIntroduction Macadamia integriflora (family Proteaceae) is an endemic Australian plant that has been used for thousands of years as a food. It is known to contain high levels of medium chain saturated fatty acids, raising the possibility that they may be useful in the treatment of Giardiasis Methods. Macadamia nuts were extracted with various solvents and tested for inhibitory activity against the gastrointestinal protozoal parasite Giardia duodenalis using colorimetric cell proliferation assays. Toxicity was evaluated using an Artemia franciscana nauplii bioassay. Results. Methanol, water and ethyl acetate extracts of macadamia nuts significantly inhibited G. duodenalis proliferation. The water extract was particularly potent, with an IC50 of 13.7 µg/ml. The methanol and ethyl acetate extracts, whilst less potent, also displayed good anti-Giardial activity (with IC50 values of approximately 125.2 and 143.5 µg/ml respectively). The chloroform and hexane extracts were ineffective as proliferation inhibitors, with no significant difference to the untreated control levels. With the exception of the water extract, all extracts were non-toxic or of low toxicity in the Artemia nauplii assay. Discussion. The antiproliferative activity and low toxicity of these extracts indicate that macadamia nut may be useful in the treatment of Giardiasis.
dc.description.peerreviewedNo
dc.description.publicationstatusYes
dc.format.extent12275 bytes
dc.format.mimetypeapplication/pdf
dc.publisher.urihttps://www.ascept.org/annual-scientific-meetings/
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofconferencenameASCEPT 2014
dc.relation.ispartofconferencetitleASCEPT 2014
dc.relation.ispartofdatefrom2014-12-06
dc.relation.ispartofdateto2014-12-11
dc.relation.ispartoflocationMelbourne Australia
dc.rights.retentionY
dc.subject.fieldofresearchPlant Biology not elsewhere classified
dc.subject.fieldofresearchcode060799
dc.titleMacadamia nut as an anti-Giardial agent
dc.typeConference output
dc.type.descriptionE3 - Conferences (Extract Paper)
dc.type.codee3
gro.facultyFaculty of Science, Environment, Engineering and Technology
gro.rights.copyright© The Author(s) 2014. The attached file is reproduced here in accordance with the copyright policy of the publisher. For information about this conference please refer to the conference’s website or contact the authors.
gro.hasfulltextFull Text
gro.griffith.authorCock, Ian E.
gro.griffith.authorMcDonnell, Ann A.
gro.griffith.authorP, Joseph S.


Files in this item

This item appears in the following Collection(s)

  • Conference outputs
    Contains papers delivered by Griffith authors at national and international conferences.

Show simple item record