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dc.contributor.authorVelasquez, Johana Tello
dc.contributor.authorWatts, Michelle E
dc.contributor.authorTodorovic, Michael
dc.contributor.authorNazareth, Lynnmaria
dc.contributor.authorPastrana, Erika
dc.contributor.authorDiaz-Nido, Javier
dc.contributor.authorLim, Filip
dc.contributor.authorEkberg, Jenny AK
dc.contributor.authorQuinn, Ronald J
dc.contributor.authorSt John, James A
dc.date.accessioned2017-05-03T15:27:05Z
dc.date.available2017-05-03T15:27:05Z
dc.date.issued2014
dc.identifier.issn1932-6203
dc.identifier.doi10.1371/journal.pone.0111787
dc.identifier.urihttp://hdl.handle.net/10072/64477
dc.description.abstractOne of the promising strategies for neural repair therapies is the transplantation of olfactory ensheathing cells (OECs) which are the glial cells of the olfactory system. We evaluated the effects of curcumin on the behaviour of mouse OECs to determine if it could be of use to further enhance the therapeutic potential of OECs. Curcumin, a natural polyphenol compound found in the spice turmeric, is known for its anti-cancer properties at doses over 10 卬 and often at 50 卬 and it exerts its effects on cancer cells in part by activation of MAP kinases. In contrast, we found that low-dose curcumin (0.5 卩 applied to OECs strikingly modulated the dynamic morphology, increased the rate of migration by up to 4-fold, and promoted significant proliferation of the OECs. Most dramatically, low-dose curcumin stimulated a 10-fold increase in the phagocytic activity of OECs. All of these potently stimulated behavioural characteristics of OECs are favourable for neural repair therapies. Importantly, low-dose curcumin gave a transient activation of p38 kinases, which is in contrast to the high dose curcumin effects on cancer cells in which these MAP kinases tend to undergo prolonged activation. Low-dose curcumin mediated effects on OECs demonstrate cell-type specific stimulation of p38 and ERK kinases. These results constitute the first evidence that low-dose curcumin can modulate the behaviour of olfactory glia into a phenotype potentially more favourable for neural repair and thereby improve the therapeutic use of OECs for neural repair therapies.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent14848216 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherPublic Library of Science
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationY
dc.relation.ispartofpagefrome111787-1
dc.relation.ispartofpagetoe111787-15
dc.relation.ispartofissue10
dc.relation.ispartofjournalPloS One
dc.relation.ispartofvolume9
dc.rights.retentionY
dc.subject.fieldofresearchCentral Nervous System
dc.subject.fieldofresearchPeripheral Nervous System
dc.subject.fieldofresearchcode110903
dc.subject.fieldofresearchcode110905
dc.titleLow-dose curcumin stimulates proliferation, migration and phagocytic activity of olfactory ensheathing cells
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://www.plos.org/journals/license.html
gro.facultyGriffith Sciences, Griffith Institute for Drug Discovery
gro.rights.copyright© 2014 Velasquez et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution License CCAL. (http://www.plos.org/journals/license.html)
gro.hasfulltextFull Text
gro.griffith.authorQuinn, Ronald J.
gro.griffith.authorTodorovic, Michael
gro.griffith.authorSt John, James A.
gro.griffith.authorEkberg, Jenny A.
gro.griffith.authorTello Velasquez, Johana P.
gro.griffith.authorWatts, Michelle E.
gro.griffith.authorNazareth, Lynn


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