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  • Olfactory ensheathing cells are the main phagocytic cells that remove axon debris during early development of the olfactory system

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    Author(s)
    Nazareth, Lynnmaria
    Lineburg, Katie E
    Chuah, Meng Inn
    Velasquez, Johana Tello
    Chehrehasa, Fatemeh
    St John, James A
    Ekberg, Jenny AK
    Griffith University Author(s)
    St John, James A.
    Ekberg, Jenny A.
    Year published
    2015
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    Abstract
    During development of the primary olfactory system, axon targeting is inaccurate and axons inappropriately project within the target layer or over-project into the deeper layers of the olfactory bulb. As a consequence there is considerable apoptosis of primary olfactory neurons during embryonic and postnatal development and axons of the degraded neurons need to be removed. Olfactory ensheathing cells (OECs) are the glia of the primary olfactory nerve and are known to phagocytose axon debris in the adult and postnatal animal. However it is unclear when phagocytosis by OECs first commences. We have investigated the onset of ...
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    During development of the primary olfactory system, axon targeting is inaccurate and axons inappropriately project within the target layer or over-project into the deeper layers of the olfactory bulb. As a consequence there is considerable apoptosis of primary olfactory neurons during embryonic and postnatal development and axons of the degraded neurons need to be removed. Olfactory ensheathing cells (OECs) are the glia of the primary olfactory nerve and are known to phagocytose axon debris in the adult and postnatal animal. However it is unclear when phagocytosis by OECs first commences. We have investigated the onset of phagocytosis by OECs in the developing mouse olfactory system by utilizing two transgenic reporter lines: OMP-ZsGreen mice which express bright green fluorescent protein in primary olfactory neurons and S100߭DsRed mice which express red fluorescent protein in OECs. In crosses of these mice, the fate of the degraded axon debris is easily visualized. We found evidence of axon degradation at E13.5. Phagocytosis of the primary olfactory axon debris by OECs was first detected at E14.5. Phagocytosis of axon debris continued into the postnatal animal during the period when there was extensive mis-targeting of olfactory axons. Macrophages were often present in close proximity to OECs but they contributed only a minor role to clearing the axon debris, even after widespread degeneration of olfactory neurons by unilateral bulbectomy and methimazole treatment. These results demonstrate that from early in embryonic development OECs are the primary phagocytic cells of the primary olfactory nerve.
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    Journal Title
    Journal of Comparative Neurology
    DOI
    https://doi.org/10.1002/cne.23694
    Copyright Statement
    © 2014 Wiley Periodicals, Inc.. This is the pre-peer reviewed version of the following article: Olfactory ensheathing cells are the main phagocytic cells that remove axon debris during early development of the olfactory system, Journal of Comparative Neurology, which has been published in final form at dx.doi.org/10.1002/cne.23694.
    Subject
    Zoology
    Neurosciences
    Central nervous system
    Peripheral nervous system
    Medical physiology
    Publication URI
    http://hdl.handle.net/10072/64499
    Collection
    • Journal articles

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