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  • Osteoporosis and bisphosphonates-related osteonecrosis of the jaw: Not just a sporadic coincidence - A multi-centre study

    Author(s)
    Otto, Sven
    Abu-Id, Mario Hakim
    Fedele, Stefano
    Warnke, Patrick H.
    Becker, Stephan T.
    Kolk, Andreas
    Mücke, Thomas
    Mast, Gerson
    Köhnke, Robert
    Volkmer, Elias
    Haasters, Florian
    Lieger, Olivier
    Iizuka, Tateyuki
    Porter, Stephen
    Campisi, Giuseppina
    Colella, Giuseppe
    Ploder, Oliver
    Neff, Andreas
    Wiltfang, Jörg
    Ehrenfeld, Michael
    Kreusch, Thomas
    Wolff, Klaus-Dietrich
    Stürzenbaum, Stephen R.
    Schieker, Matthias
    Pautke, Christoph
    Griffith University Author(s)
    Warnke, Patrick H.
    Year published
    2011
    Metadata
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    Abstract
    Introduction Bisphosphonates (BPs) are powerful drugs that inhibit bone metabolism. Adverse side effects are rare but potentially severe such as bisphosphonate-related osteonecrosis of the jaw (BRONJ). To date, research has primarily focused on the development and progression of BRONJ in cancer patients with bone metastasis, who have received high dosages of BPs intravenously. However, a potential dilemma may arise from a far larger cohort, namely the millions of osteoporosis patients on long-term oral BP therapy. Patients and methods This current study assessed 470 cases of BRONJ diagnosed between 2004 and 2008 at eleven ...
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    Introduction Bisphosphonates (BPs) are powerful drugs that inhibit bone metabolism. Adverse side effects are rare but potentially severe such as bisphosphonate-related osteonecrosis of the jaw (BRONJ). To date, research has primarily focused on the development and progression of BRONJ in cancer patients with bone metastasis, who have received high dosages of BPs intravenously. However, a potential dilemma may arise from a far larger cohort, namely the millions of osteoporosis patients on long-term oral BP therapy. Patients and methods This current study assessed 470 cases of BRONJ diagnosed between 2004 and 2008 at eleven different European clinical centres and has resulted in the identification of a considerable cohort of osteoporosis patients suffering from BRONJ. Each patient was clinically examined and a detailed medical history was raised. Results In total, 37/470 cases (7.8%) were associated with oral BP therapy due to osteoporosis. The majority (57%) of affected individuals did not have any risk factors for BRONJ as defined by the American Association of Oral and Maxillofacial Surgery. The average duration of BP intake of patients without risk factors was longer and the respective patients were older compared to patients with risk factors, but no statistical significant difference was found. In 78% of patients the duration of oral BP therapy exceeded 3 years prior to BRONJ diagnosis. Discussion The results from this study suggest that the relative frequency of osteoporosis patients on oral BPs suffering from BRONJ is higher than previously reported. There is an urgent need to substantiate epidemiological characteristics of BRONJ in large cohorts of individuals.
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    Journal Title
    Journal of Cranio-Maxillofacial Surgery
    Volume
    39
    Issue
    4
    DOI
    https://doi.org/10.1016/j.jcms.2010.05.009
    Subject
    Dentistry not elsewhere classified
    Clinical Sciences
    Dentistry
    Publication URI
    http://hdl.handle.net/10072/64709
    Collection
    • Journal articles

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