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dc.contributor.authorOtto, Sven
dc.contributor.authorAbu-Id, Mario Hakim
dc.contributor.authorFedele, Stefano
dc.contributor.authorWarnke, Patrick H.
dc.contributor.authorBecker, Stephan T.
dc.contributor.authorKolk, Andreas
dc.contributor.authorMücke, Thomas
dc.contributor.authorMast, Gerson
dc.contributor.authorKöhnke, Robert
dc.contributor.authorVolkmer, Elias
dc.contributor.authorHaasters, Florian
dc.contributor.authorLieger, Olivier
dc.contributor.authorIizuka, Tateyuki
dc.contributor.authorPorter, Stephen
dc.contributor.authorCampisi, Giuseppina
dc.contributor.authorColella, Giuseppe
dc.contributor.authorPloder, Oliver
dc.contributor.authorNeff, Andreas
dc.contributor.authorWiltfang, Jörg
dc.contributor.authorEhrenfeld, Michael
dc.contributor.authorKreusch, Thomas
dc.contributor.authorWolff, Klaus-Dietrich
dc.contributor.authorStürzenbaum, Stephen R.
dc.contributor.authorSchieker, Matthias
dc.contributor.authorPautke, Christoph
dc.description.abstractIntroduction Bisphosphonates (BPs) are powerful drugs that inhibit bone metabolism. Adverse side effects are rare but potentially severe such as bisphosphonate-related osteonecrosis of the jaw (BRONJ). To date, research has primarily focused on the development and progression of BRONJ in cancer patients with bone metastasis, who have received high dosages of BPs intravenously. However, a potential dilemma may arise from a far larger cohort, namely the millions of osteoporosis patients on long-term oral BP therapy. Patients and methods This current study assessed 470 cases of BRONJ diagnosed between 2004 and 2008 at eleven different European clinical centres and has resulted in the identification of a considerable cohort of osteoporosis patients suffering from BRONJ. Each patient was clinically examined and a detailed medical history was raised. Results In total, 37/470 cases (7.8%) were associated with oral BP therapy due to osteoporosis. The majority (57%) of affected individuals did not have any risk factors for BRONJ as defined by the American Association of Oral and Maxillofacial Surgery. The average duration of BP intake of patients without risk factors was longer and the respective patients were older compared to patients with risk factors, but no statistical significant difference was found. In 78% of patients the duration of oral BP therapy exceeded 3 years prior to BRONJ diagnosis. Discussion The results from this study suggest that the relative frequency of osteoporosis patients on oral BPs suffering from BRONJ is higher than previously reported. There is an urgent need to substantiate epidemiological characteristics of BRONJ in large cohorts of individuals.
dc.publisherChurchill Livingstone
dc.publisher.placeUnited Kingdom
dc.relation.ispartofjournalJournal of Cranio-Maxillofacial Surgery
dc.subject.fieldofresearchDentistry not elsewhere classified
dc.subject.fieldofresearchClinical Sciences
dc.titleOsteoporosis and bisphosphonates-related osteonecrosis of the jaw: Not just a sporadic coincidence - A multi-centre study
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorWarnke, Patrick H.

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