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  • Development of novel chitin/nanosilver composite scaffolds for wound dressing applications

    Author(s)
    Madhumathi, K.
    Sudheesh Kumar, P.
    Abhilash, S.
    Sreeja, V.
    Tamura, H.
    Manzoor, K.
    Nair, S.
    Jayakumar, R.
    Griffith University Author(s)
    Pandiyan Thodi, Sudheesh Kumar
    Year published
    2010
    Metadata
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    Abstract
    Antibiotic resistance of microorganisms is one of the major problems faced in the field of wound care and management resulting in complications like infection and delayed wound healing. Currently a lot of research is focused on developing newer antimicrobials to treat wounds infected with antibiotic resistant microorganisms. Silver has been used as an antimicrobial agent for a long time in the form of metallic silver and silver sulfadiazine ointments. Recently silver nanoparticles have come up as a potent antimicrobial agent and are finding diverse medical applications ranging from silver based dressings to silver coated ...
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    Antibiotic resistance of microorganisms is one of the major problems faced in the field of wound care and management resulting in complications like infection and delayed wound healing. Currently a lot of research is focused on developing newer antimicrobials to treat wounds infected with antibiotic resistant microorganisms. Silver has been used as an antimicrobial agent for a long time in the form of metallic silver and silver sulfadiazine ointments. Recently silver nanoparticles have come up as a potent antimicrobial agent and are finding diverse medical applications ranging from silver based dressings to silver coated medical devices. Chitin is a natural biopolymer with properties like biocompatibility and biodegradability. It is widely used as a scaffold for tissue engineering applications. In this work, we developed and characterized novel chitin/nanosilver composite scaffolds for wound healing applications. The antibacterial, blood clotting and cytotoxicity of the prepared composite scaffolds were also studied. These chitin/nanosilver composite scaffolds were found to be bactericidal against S. aureus and E. coli and good blood clotting ability. These results suggested that these chitin/nanosilver composite scaffolds could be used for wound healing applications.
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    Journal Title
    Journal of Materials Science: Materials in Medicine
    Volume
    21
    Issue
    2
    DOI
    https://doi.org/10.1007/s10856-009-3877-z
    Subject
    Materials Engineering not elsewhere classified
    Biomedical Engineering not elsewhere classified
    Biomedical Engineering
    Materials Engineering
    Publication URI
    http://hdl.handle.net/10072/64729
    Collection
    • Journal articles

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