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dc.contributor.authorT. Becker, Stephan
dc.contributor.authorBolte, Hendrik
dc.contributor.authorKrapf, Oliver
dc.contributor.authorSeitz, Hermann
dc.contributor.authorDouglas, Timothy
dc.contributor.authorSivananthan, Sureshan
dc.contributor.authorWiltfang, Jörg
dc.contributor.authorSherry, Eugene
dc.contributor.authorH. Warnke, Patrick
dc.date.accessioned2017-05-03T14:41:48Z
dc.date.available2017-05-03T14:41:48Z
dc.date.issued2009
dc.identifier.issn13688375
dc.identifier.doi10.1016/j.oraloncology.2009.07.004
dc.identifier.urihttp://hdl.handle.net/10072/64734
dc.description.abstractThe aim of this study was to evaluate the ability of computer assisted designed (CAD) synthetic hydroxyapatite and tricalciumphosphate blocks to serve as precise scaffolds for intramuscular bone induction in a rat model. A central channel to allow for vessel pedicle or nerve integration was added. Natural bovine hydroxyapatite blocks served as controls to evaluate and compare biocompatibility of the new matrices. Individually designed 3D-printed rounded and porous hydroxyapatite (HA) and tricalcium phosphate (TCP) blocks were placed in pouches in the Musculus latissimus dorsi in 12 Lewis rats bilaterally. Bovine hydroxyapatite blocks with and without a central channel served as controls. Simultaneously, 200 姠rhBMP-2 in 1 ml sodium chloride was injected on both sides. For 8 weeks, bone generation was monitored by computer tomography and fluorescence labeling. The increase rates of bone density in CT examinations were higher in the HA groups (184-220 HU 8 weeks after implantation) compared to the TCP group (18 HU; p < 0.0001). Microradiography and fluorescence microscopy 8 weeks after implantation showed new bone formation for all materials tested. For all scaffolds, toluidine staining revealed vital bone directly on the scaffold materials but also in the gaps between. It can be concluded from our data that the specially shaped hydroxyapatite and tricalcium phosphate blocks tested against the bovine hydroxyapatite blocks showed good biocompatibility and osteoinductivity in vivo. Further studies should explore if the stability of the individually designed blocks is sufficient to cultivate larger replacements without an external matrix for support.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeUnited Kingdom
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrome181
dc.relation.ispartofpagetoe188
dc.relation.ispartofissue11
dc.relation.ispartofjournalOral Oncology
dc.relation.ispartofvolume45
dc.rights.retentionY
dc.subject.fieldofresearchDentistry not elsewhere classified
dc.subject.fieldofresearchDentistry
dc.subject.fieldofresearchOncology and Carcinogenesis
dc.subject.fieldofresearchPublic Health and Health Services
dc.subject.fieldofresearchcode110599
dc.subject.fieldofresearchcode1105
dc.subject.fieldofresearchcode1112
dc.subject.fieldofresearchcode1117
dc.titleEndocultivation: 3D printed customized porous scaffolds for heterotopic bone induction
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorWarnke, Patrick H.


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