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dc.contributor.authorH. Warnke, Patrick
dc.contributor.authorA. J. Russo, Paul
dc.contributor.authorHopfenziz, Martin
dc.contributor.authorKurz, Bodo
dc.contributor.authorT. Becker, Stephan
dc.contributor.authorSherry, Eugene
dc.contributor.authorSpringer, Ingo
dc.contributor.authorSivananthan, Sureshan
dc.date.accessioned2017-05-03T14:41:47Z
dc.date.available2017-05-03T14:41:47Z
dc.date.issued2010
dc.identifier.issn10492275
dc.identifier.doi10.1097/SCS.0b013e3181c50fc2
dc.identifier.urihttp://hdl.handle.net/10072/64744
dc.description.abstractBackground: Despite being impervious to surveillance by the adaptive immune system because of its lack of vascularity, infection of the nasal and auricular cartilage after surgery such as rhinoplasty or otoplasty is rare. Why is this so? Our goal was to determine whether the expression of antimicrobial peptides provides a previously unrecognized nonepithelial layer of innate immune defense within the nasal and auricular cartilage. Materials and Methods: Seven samples of nasal septum cartilage and 2 biopsies from auricular cartilage grafts were harvested during rhinoplasty and otoplasty procedures. Ten cadaveric samples of auricular and 9 samples of nasal cartilage were also obtained. Immunohistochemical staining was directed against the human ߭defensin antimicrobial peptides (hBD) 1, 2, and 3. A semiquantitative analysis was performed to measure immunoreactivity. Results: All 3 human ߭defensins were detected along the perichondral line and within the cartilage matrix in the nasal and auricular samples. Areas with positive immunohistochemical staining were also detected within chondrocyte cytoplasm. Conclusions: We provide the first evidence of antimicrobial peptide expression (hBD-1, -2 and -3) within the perichondrium and cartilage matrix layers of the nasal and auricular cartilage. This previously unrecognized innate immune function of perichondrocytes and chondrocytes may explain the resistance of the nasal and auricular cartilage to infection after surgical procedures despite the absence of a vascular system.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherLippincott Williams & Wilkins
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom198
dc.relation.ispartofpageto201
dc.relation.ispartofissue1
dc.relation.ispartofjournalJournal of Craniofacial Surgery
dc.relation.ispartofvolume21
dc.rights.retentionY
dc.subject.fieldofresearchDentistry not elsewhere classified
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchcode110599
dc.subject.fieldofresearchcode1103
dc.titleAntimicrobial peptide immunity protects human nasal and auricular cartilage against infection
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorWarnke, Patrick H.


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