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dc.contributor.authorDouglas, Timothy
dc.contributor.authorPamula, Elzbieta
dc.contributor.authorHauk, Dominik
dc.contributor.authorWiltfang, Jorg
dc.contributor.authorSivananthan, Sureshan
dc.contributor.authorSherry, Eugene
dc.contributor.authorH. Warnke, Patrick
dc.date.accessioned2017-05-03T14:41:48Z
dc.date.available2017-05-03T14:41:48Z
dc.date.issued2009
dc.identifier.issn09574530
dc.identifier.doi10.1007/s10856-009-3756-7
dc.identifier.urihttp://hdl.handle.net/10072/64745
dc.description.abstractPoly-lactic-glycolic acid (PLGA) has been widely used as a scaffold material for bone tissue engineering applications. 3D sponge-like porous scaffolds have previously been generated through a solvent casting and salt leaching technique. In this study, polymer-ceramic composite scaffolds were created by immersing PLGA scaffolds in simulated body fluid, leading to the formation of a hydroxyapatite (HAP) coating. The presence of a HAP layer was confirmed using scanning electron microscopy, energy dispersive X-ray spectroscopy and Fourier transform infrared spectroscopy in attenuated total reflection mode. HAP-coated PLGA scaffolds were tested for their biocompatibility in vitro using human osteoblast cell cultures. Biocompatibility was assessed by standard tests for cell proliferation (MTT, WST), as well as fluorescence microscopy after standard cell vitality staining procedures. It was shown that PLGA-HAP composites support osteoblast growth and vitality, paving the way for applications as bone tissue engineering scaffolds.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherSpringer New York LLC
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom1909
dc.relation.ispartofpageto1915
dc.relation.ispartofissue9
dc.relation.ispartofjournalJournal of Materials Science: Materials in Medicine
dc.relation.ispartofvolume20
dc.rights.retentionY
dc.subject.fieldofresearchDentistry not elsewhere classified
dc.subject.fieldofresearchBiomedical Engineering
dc.subject.fieldofresearchMaterials Engineering
dc.subject.fieldofresearchcode110599
dc.subject.fieldofresearchcode0903
dc.subject.fieldofresearchcode0912
dc.titlePorous polymer/hydroxyapatite scaffolds: Characterization and biocompatibility investigations
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorWarnke, Patrick H.


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