dc.contributor.author | Chen, Shu | |
dc.contributor.author | Wang, Xiongfei | |
dc.contributor.author | Wu, Xiaolian | |
dc.contributor.author | Wei, Ming Q | |
dc.contributor.author | Zhang, Bin | |
dc.contributor.author | Liu, Xiaosong | |
dc.contributor.author | Wang, Yuejian | |
dc.date.accessioned | 2017-05-03T14:42:05Z | |
dc.date.available | 2017-05-03T14:42:05Z | |
dc.date.issued | 2014 | |
dc.identifier.issn | 0008-8749 | |
dc.identifier.doi | 10.1016/j.cellimm.2014.06.002 | |
dc.identifier.uri | http://hdl.handle.net/10072/64751 | |
dc.description.abstract | IL-10 signalling blockade by intra-peritoneal injection of anti-IL-10 receptor antibodies at the time of immunization enhances vaccine induced CD8+ T cell responses and promotes bacteria, parasitic and viral control. We now show that blockade of IL-10 signalling at the time of immunization enhances vaccine induced antigen specific CD8+ T cell responses to both dominant and subdominant CTL epitopes. Injection of anti-IL-10 receptor antibodies subcutaneous at the time of immunization also enhances CD8+ T cell responses. Furthermore, IL-10 signalling blockade at the time of a Human papillomavirus 16 E7 peptide/LPS immunization, prevents HPV16 E7 transformed TC-1 tumour growth in mice. Immunization in the presence of anti-IL-10R antibodies and Monophosphoryl lipid A, generates antigen specific CD8+ T cell responses similar to immunization with LPS. Our results suggest that immunization and IL-10 signalling blockade may provide a novel way for the development of therapeutic vaccines against cancer. | |
dc.description.peerreviewed | Yes | |
dc.description.publicationstatus | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Elsevier | |
dc.publisher.place | United States | |
dc.relation.ispartofstudentpublication | N | |
dc.relation.ispartofpagefrom | 145 | |
dc.relation.ispartofpageto | 151 | |
dc.relation.ispartofissue | 1 | |
dc.relation.ispartofjournal | Cellular Immunology | |
dc.relation.ispartofvolume | 290 | |
dc.rights.retention | Y | |
dc.subject.fieldofresearch | Immunology | |
dc.subject.fieldofresearchcode | 3204 | |
dc.title | IL-10 signalling blockade at the time of immunization inhibits Human papillomavirus 16 E7 transformed TC-1 tumour cells growth in mice | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Wei, Ming Q. | |