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dc.contributor.authorChen, Shu
dc.contributor.authorWang, Xiongfei
dc.contributor.authorWu, Xiaolian
dc.contributor.authorWei, Ming Q
dc.contributor.authorZhang, Bin
dc.contributor.authorLiu, Xiaosong
dc.contributor.authorWang, Yuejian
dc.date.accessioned2017-05-03T14:42:05Z
dc.date.available2017-05-03T14:42:05Z
dc.date.issued2014
dc.identifier.issn0008-8749
dc.identifier.doi10.1016/j.cellimm.2014.06.002
dc.identifier.urihttp://hdl.handle.net/10072/64751
dc.description.abstractIL-10 signalling blockade by intra-peritoneal injection of anti-IL-10 receptor antibodies at the time of immunization enhances vaccine induced CD8+ T cell responses and promotes bacteria, parasitic and viral control. We now show that blockade of IL-10 signalling at the time of immunization enhances vaccine induced antigen specific CD8+ T cell responses to both dominant and subdominant CTL epitopes. Injection of anti-IL-10 receptor antibodies subcutaneous at the time of immunization also enhances CD8+ T cell responses. Furthermore, IL-10 signalling blockade at the time of a Human papillomavirus 16 E7 peptide/LPS immunization, prevents HPV16 E7 transformed TC-1 tumour growth in mice. Immunization in the presence of anti-IL-10R antibodies and Monophosphoryl lipid A, generates antigen specific CD8+ T cell responses similar to immunization with LPS. Our results suggest that immunization and IL-10 signalling blockade may provide a novel way for the development of therapeutic vaccines against cancer.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom145
dc.relation.ispartofpageto151
dc.relation.ispartofissue1
dc.relation.ispartofjournalCellular Immunology
dc.relation.ispartofvolume290
dc.rights.retentionY
dc.subject.fieldofresearchImmunology
dc.subject.fieldofresearchcode3204
dc.titleIL-10 signalling blockade at the time of immunization inhibits Human papillomavirus 16 E7 transformed TC-1 tumour cells growth in mice
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorWei, Ming Q.


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