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  • Endocultivation: Does delayed application of BMP improve intramuscular heterotopic bone formation?

    Author(s)
    H. Warnke, Patrick
    Bolte, Hendrik
    Schünemann, Kristina
    Nitsche, Tobias
    Sivananthan, Sureshan
    Sherry, Eugene
    Douglas, Timothy
    Wiltfang, Jörg
    T. Becker, Stephan
    Griffith University Author(s)
    Warnke, Patrick H.
    Year published
    2010
    Metadata
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    Abstract
    Introduction The time point of Bone morphogenetic protein (BMP) delivery on matrices in vivo may play an important role. Delayed application could be advantageous as this would allow soft tissue (ST) ingrowth and vascularisation of scaffolds prior to BMP-loading. The aim of this study was to compare the application of BMP injected simultaneously during matrix implantation with delayed application four weeks after matrix implantation for endocultivation in a rat model. Material and methods Bovine hydroxyapatite blocks were placed in pouches in the Musculus latissimus dorsi in 6 Lewis rats unilaterally to allow for soft tissue ...
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    Introduction The time point of Bone morphogenetic protein (BMP) delivery on matrices in vivo may play an important role. Delayed application could be advantageous as this would allow soft tissue (ST) ingrowth and vascularisation of scaffolds prior to BMP-loading. The aim of this study was to compare the application of BMP injected simultaneously during matrix implantation with delayed application four weeks after matrix implantation for endocultivation in a rat model. Material and methods Bovine hydroxyapatite blocks were placed in pouches in the Musculus latissimus dorsi in 6 Lewis rats unilaterally to allow for soft tissue ingrowth. Four weeks later, a second block was inserted on the contralateral side of each rat. At that time point, 100 姠rhBMP-2 in 2 ml sodium chloride was injected on both sides to induce bone formation. For eight weeks, bone regeneration was monitored by computed tomography (CT) and fluorescent labelling. Results The simultaneous and delayed BMP application groups were significantly different (p = 0.01). Slightly lower bone densities were seen for the delayed BMP application with a mean of 588 Hounsfield Units (HU) (standard deviation (SD) 30 HU). Simultaneous BMP application revealed slightly higher densities with a mean of 633 HU (SD 30 HU). The largest differences were observed when comparing bone density directly after implantation or at the end of the observation period (p < 0.0001). Conclusion Bone density was slightly lower in the case of delayed application of BMP-2. The increase of bone density after application of BMP-2 was similar for both groups. Thus, delayed application of BMP had no advantageous effect in this particular study design. Further studies are needed to explore if varying delays, different material designs or special BMP application devices may alter these results.
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    Journal Title
    Journal of Cranio-Maxillofacial Surgery
    Volume
    38
    Issue
    1
    DOI
    https://doi.org/10.1016/j.jcms.2009.09.002
    Subject
    Dentistry not elsewhere classified
    Clinical Sciences
    Dentistry
    Publication URI
    http://hdl.handle.net/10072/64756
    Collection
    • Journal articles

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