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dc.contributor.authorChan, Raymond Javan
dc.contributor.authorWebster, Joan
dc.contributor.authorChung, Bryan
dc.contributor.authorMarquart, Louise
dc.contributor.authorAhmed, Muhtashimuddin
dc.contributor.authorGarantziotis, Stuart
dc.date.accessioned2017-05-03T15:51:14Z
dc.date.available2017-05-03T15:51:14Z
dc.date.issued2014
dc.identifier.issn1471-2407
dc.identifier.doi10.1186/1471-2407-14-53
dc.identifier.urihttp://hdl.handle.net/10072/64948
dc.description.abstractBackground Radiation-induced skin reaction (RISR) is a common side effect that affects the majority of cancer patients receiving radiation treatment. RISR is often characterised by swelling, redness, pigmentation, fibrosis, and ulceration, pain, warmth, burning, and itching of the skin. The aim of this systematic review was to assess the effects of interventions which aim to prevent or manage RISR in people with cancer. Methods We searched the following databases up to November 2012: Cochrane Skin Group Specialised Register, CENTRAL (2012, Issue 11), MEDLINE (from 1946), EMBASE (from 1974), PsycINFO (from 1806), CINAHL (from 1981) and LILACS (from 1982). Randomized controlled trials evaluating interventions for preventing or managing RISR in cancer patients were included. The primary outcomes were development of RISR, and levels of RISR and symptom severity. Secondary outcomes were time taken to develop erythema or dry desquamation; quality of life; time taken to heal, a number of skin reaction and symptom severity measures; cost, participant satisfaction; ease of use and adverse effects. Where appropriate, we pooled results of randomized controlled trials using mean differences (MD) or odd ratios (OR) with 95% confidence intervals (CI). Results Forty-seven studies were included in this review. These evaluated six types of interventions (oral systemic medications; skin care practices; steroidal topical therapies; non-steroidal topical therapies; dressings and other). Findings from two meta-analyses demonstrated significant benefits of oral Wobe-Mugos E for preventing RISR (OR 0.13 (95% CI 0.05 to 0.38)) and limiting the maximal level of RISR (MD -0.92 (95% CI -1.36 to -0.48)). Another meta-analysis reported that wearing deodorant does not influence the development of RISR (OR 0.80 (95% CI 0.47 to 1.37)). Conclusions Despite the high number of trials in this area, there is limited good, comparative research that provides definitive results suggesting the effectiveness of any single intervention for reducing RISR. More research is required to demonstrate the usefulness of a wide range of products that are being used for reducing RISR. Future efforts for reducing RISR severity should focus on promising interventions, such as Wobe-Mugos E and oral zinc.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent1500649 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherBioMed Central
dc.publisher.placeUnited Kingdom
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom53-1
dc.relation.ispartofpageto53-19
dc.relation.ispartofissue1
dc.relation.ispartofjournalBMC Cancer
dc.relation.ispartofvolume14
dc.rights.retentionY
dc.subject.fieldofresearchAcute care
dc.subject.fieldofresearchOncology and carcinogenesis
dc.subject.fieldofresearchcode420501
dc.subject.fieldofresearchcode3211
dc.titlePrevention and treatment of acute radiation-induced skin reactions: A systematic review and meta-analysis of randomized controlled trials
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by/2.0
gro.facultyGriffith Health, School of Nursing and Midwifery
gro.description.notepublicPage numbers are not for citation purposes. Instead, this article has the unique article number of 53.
gro.rights.copyright© 2014 Chan et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorWebster, Joan
gro.griffith.authorChan, Ray
gro.griffith.authorGarantziotis, Stuart


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