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dc.contributor.authorBrannstrom, Mats
dc.contributor.authorJohannesson, Liza
dc.contributor.authorDahm-Kahler, Pernilla
dc.contributor.authorEnskog, Anders
dc.contributor.authorMolne, Johan
dc.contributor.authorKvarnstrom, Niclas
dc.contributor.authorDiaz-Garcia, Cesar
dc.contributor.authorHanafy, Ashraf
dc.contributor.authorLundmark, Cecilia
dc.contributor.authorMarcickiewicz, Janusz
dc.contributor.authorGabel, Markus
dc.contributor.authorGroth, Klaus
dc.contributor.authorAkouri, Randa
dc.contributor.authorEklind, Saskia
dc.contributor.authorHolgersson, Jan
dc.contributor.authorTzakis, Andreas
dc.contributor.authorOlausson, Michael
dc.date.accessioned2017-11-28T12:00:44Z
dc.date.available2017-11-28T12:00:44Z
dc.date.issued2014
dc.identifier.issn15565653
dc.identifier.doi10.1016/j.fertnstert.2014.02.024
dc.identifier.urihttp://hdl.handle.net/10072/64954
dc.description.abstractObjective To report the 6-month results of the first clinical uterus transplantation (UTx) trial. This type of transplantation may become a treatment of absolute uterine-factor infertility (AUFI). Design Prospective observational study. Setting University hospital. Patient(s) Nine AUFI women and their live uterine donors, the majority being mothers. Intervention(s) Live-donor UTx and low-dose induction immunosuppression. Main Outcome Measure(s) Data from preoperative investigations, surgery and follow-up for 6 months. Result(s) Durations of donor and recipient surgery ranged from 10 to 13 hours and from 4 to 6 hours, respectively. No immediate perioperative complications occurred in any of the recipients. After 6 months, seven uteri remained viable with regular menses. Mild rejection episodes occurred in four of these patients. These rejection episodes were effectively reversed by corticosteroid boluses. The two graft losses were because of acute bilateral thrombotic uterine artery occlusions and persistent intrauterine infection. Conclusion(s) The results demonstrate the feasibility of live-donor UTx with a low-dose immunosuppressive protocol.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom1228
dc.relation.ispartofpageto1236
dc.relation.ispartofissue5
dc.relation.ispartofjournalFertility and Sterility
dc.relation.ispartofvolume101
dc.rights.retentionY
dc.subject.fieldofresearchPaediatrics and Reproductive Medicine not elsewhere classified
dc.subject.fieldofresearchClinical Sciences not elsewhere classified
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchPaediatrics and Reproductive Medicine
dc.subject.fieldofresearchPublic Health and Health Services
dc.subject.fieldofresearchcode111499
dc.subject.fieldofresearchcode110399
dc.subject.fieldofresearchcode1103
dc.subject.fieldofresearchcode1114
dc.subject.fieldofresearchcode1117
dc.titleFirst clinical uterus transplantation trial: A six-month report
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorHanafy, Ashraf


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