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dc.contributor.authorDu, Zhibin
dc.contributor.authorIvanovski, Saso
dc.contributor.authorHamlet, Stephen M
dc.contributor.authorFeng, Jian Q
dc.contributor.authorXiao, Yin
dc.date.accessioned2018-10-05T01:31:06Z
dc.date.available2018-10-05T01:31:06Z
dc.date.issued2016
dc.identifier.issn1523-0899
dc.identifier.doi10.1111/cid.12257
dc.identifier.urihttp://hdl.handle.net/10072/64969
dc.description.abstractBackground Osteocytes, the most abundant cells in bone, have multiple functions, including acting as mechanosensors and regulating mineralization. It is clear that osteocytes influence bone remodeling by controlling the differentiation and activity of osteoblasts and osteoclasts. Determining the relationship between titanium implants and osteocytes may therefore benefit our understanding of the process of osseointegration. Purpose The aim of this study was to visualize the ultrastructural relationship between osteocytes and the titanium implant surface following osseointegration in vivo. Materials and Methods Titanium implants were placed in the maxillary molar regions of eight female Sprague Dawley rats, 3 months old. The animals were sacrificed 8 weeks after implantation, and undecalcified tissue sections were prepared. Resin-cast samples were subsequently acid-etched with 37% phosphoric acid prior to examination using scanning electron microscopy. Results Compared with mature bone, where the osteocytes were arranged in an ordered fashion, the osteocytes appeared less organized in the newly formed bone around the titanium implant. Further, a layer of mineralization with few organic components was observed on the implant surface. This study shows for the first time that osteocytes and their dendrites are directly connected with the implant surface. Conclusions This study shows the direct anchorage of osteocytes via dendritic processes to a titanium implant surface in vivo. This suggests an important regulatory role for osteocytes and their lacunar-canalicular network in maintaining long-term osseointegration.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.publisher.placeUnited Kingdom
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom270
dc.relation.ispartofpageto280
dc.relation.ispartofissue2
dc.relation.ispartofjournalClinical Implant Dentistry and Related Research
dc.relation.ispartofvolume18
dc.rights.retentionY
dc.subject.fieldofresearchDentistry
dc.subject.fieldofresearchPeriodontics
dc.subject.fieldofresearchcode3203
dc.subject.fieldofresearchcode320310
dc.titleThe ultrastructural relationship between osteocytes and dental implants following osseointegration
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorXiao, Yin


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