Toll-like receptor 4 plays significant roles during allergic rhinitis
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Allergic rhinitis is a nasal hypersensitivity and allergic diseases which leads to inflammation of nasal mucosa. Previous investigations revealed that innate immune receptors play a key role in the pathogenesis of inflammatory diseases including allergic diseases. Toll like receptors (TLRs), which are important innate immune receptors, play crucial roles in recognition of foreign antigens, including allergens, and subsequently for the induction of immune responses such as inflammation. There are several controversial reports regarding the roles of TLR4 in the pathogenesis of allergic rhinitis. This review presents current information regarding the roles of TLR4 in the pathogenesis of allergic rhinitis and the plausible mechanisms which lead to the expression and function of TLR4 in this disease
Allergologia et Immunopathologia
Copyright 2014 Sociedad Española de Inmunología Clínica y Alergología Pediátrica and Elsevier España S.L. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence (http://creativecommons.org/licenses/by-nc-nd/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.
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