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  • Genetic Analysis of GRIA2 and GRIA4 Genes in Migraine

    Author(s)
    Gasparini, Claudia
    Sutherland, Heidi
    Haupt, Larisa
    Griffiths, Lyn
    Griffith University Author(s)
    Haupt, Larisa
    Griffiths, Lyn
    Gasparini, Claudia F.
    Sutherland, Heidi
    Year published
    2014
    Metadata
    Show full item record
    Abstract
    Background Migraine is a brain disorder affecting ~12% of the Caucasian population. Genes involved in neurological, vascular, and hormonal pathways have all been implicated in predisposing individuals to developing migraine. The migraineur presents with disabling head pain and varying symptoms of nausea, emesis, photophobia, phonophobia, and occasionally visual sensory disturbances. Biochemical and genetic studies have demonstrated dysfunction of neurotransmitters: serotonin, dopamine, and glutamate in migraine susceptibility. Glutamate mediates the transmission of excitatory signals in the mammalian central nervous system ...
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    Background Migraine is a brain disorder affecting ~12% of the Caucasian population. Genes involved in neurological, vascular, and hormonal pathways have all been implicated in predisposing individuals to developing migraine. The migraineur presents with disabling head pain and varying symptoms of nausea, emesis, photophobia, phonophobia, and occasionally visual sensory disturbances. Biochemical and genetic studies have demonstrated dysfunction of neurotransmitters: serotonin, dopamine, and glutamate in migraine susceptibility. Glutamate mediates the transmission of excitatory signals in the mammalian central nervous system that affect normal brain function including cognition, memory and learning. The aim of this study was to investigate polymorphisms in the GRIA2 and GRIA4 genes, which encode subunits of the ionotropic AMPA receptor for association in an Australian Caucasian population. Methods Genotypes for each polymorphism were determined using high resolution melt analysis and the RFLP method. Results Statistical analysis showed no association between migraine and the GRIA2 and GRIA4 polymorphisms investigated. Conclusions Although the results of this study showed no significant association between the tested GRIA gene variants and migraine in our Australian Caucasian population further investigation of other components of the glutamatergic system may help to elucidate if there is a relationship between glutamatergic dysfunction and migraine.
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    Journal Title
    Headache
    Volume
    54
    Issue
    2
    DOI
    https://doi.org/10.1111/head.12234
    Subject
    Medical and Health Sciences not elsewhere classified
    Clinical Sciences
    Publication URI
    http://hdl.handle.net/10072/65060
    Collection
    • Journal articles

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