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dc.contributor.authorGasparini, Claudia
dc.contributor.authorSutherland, Heidi
dc.contributor.authorHaupt, Larisa
dc.contributor.authorGriffiths, Lyn
dc.date.accessioned2017-05-03T14:41:57Z
dc.date.available2017-05-03T14:41:57Z
dc.date.issued2014
dc.identifier.issn00178748
dc.identifier.doi10.1111/head.12234
dc.identifier.urihttp://hdl.handle.net/10072/65060
dc.description.abstractBackground Migraine is a brain disorder affecting ~12% of the Caucasian population. Genes involved in neurological, vascular, and hormonal pathways have all been implicated in predisposing individuals to developing migraine. The migraineur presents with disabling head pain and varying symptoms of nausea, emesis, photophobia, phonophobia, and occasionally visual sensory disturbances. Biochemical and genetic studies have demonstrated dysfunction of neurotransmitters: serotonin, dopamine, and glutamate in migraine susceptibility. Glutamate mediates the transmission of excitatory signals in the mammalian central nervous system that affect normal brain function including cognition, memory and learning. The aim of this study was to investigate polymorphisms in the GRIA2 and GRIA4 genes, which encode subunits of the ionotropic AMPA receptor for association in an Australian Caucasian population. Methods Genotypes for each polymorphism were determined using high resolution melt analysis and the RFLP method. Results Statistical analysis showed no association between migraine and the GRIA2 and GRIA4 polymorphisms investigated. Conclusions Although the results of this study showed no significant association between the tested GRIA gene variants and migraine in our Australian Caucasian population further investigation of other components of the glutamatergic system may help to elucidate if there is a relationship between glutamatergic dysfunction and migraine.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom303
dc.relation.ispartofpageto312
dc.relation.ispartofissue2
dc.relation.ispartofjournalHeadache
dc.relation.ispartofvolume54
dc.rights.retentionY
dc.subject.fieldofresearchMedical and Health Sciences not elsewhere classified
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchcode119999
dc.subject.fieldofresearchcode1103
dc.titleGenetic Analysis of GRIA2 and GRIA4 Genes in Migraine
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorHaupt, Larisa
gro.griffith.authorGriffiths, Lyn
gro.griffith.authorGasparini, Claudia F.
gro.griffith.authorSutherland, Heidi


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