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  • Waning vaccine immunity in teenagers primed with whole cell and acellular pertussis vaccine: recent epidemiology

    Author(s)
    Sheridan, Sarah L
    Frith, Katie
    Snelling, Thomas L
    Grimwood, Keith
    McIntyre, Peter B
    Lambert, Stephen B
    Griffith University Author(s)
    Grimwood, Keith
    Lambert, Stephen B.
    Year published
    2014
    Metadata
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    Abstract
    The recent epidemics of pertussis (whooping cough) in parts of the USA and Australia have led to the largest numbers of annual cases reported in over half a century. These epidemics demonstrated a new pattern, with particularly high rates of disease among pre-adolescents and early adolescents. These high rates of pertussis coincided with the first cohorts vaccinated with purely acellular pertussis vaccine, which replaced whole-cell pertussis (wP) vaccine in the later 1990s in the USA and Australia. Studies undertaken during these epidemics provide new evidence of more rapid waning of acellular pertussis-containing vaccines ...
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    The recent epidemics of pertussis (whooping cough) in parts of the USA and Australia have led to the largest numbers of annual cases reported in over half a century. These epidemics demonstrated a new pattern, with particularly high rates of disease among pre-adolescents and early adolescents. These high rates of pertussis coincided with the first cohorts vaccinated with purely acellular pertussis vaccine, which replaced whole-cell pertussis (wP) vaccine in the later 1990s in the USA and Australia. Studies undertaken during these epidemics provide new evidence of more rapid waning of acellular pertussis-containing vaccines and longer-term protection from effective wP-containing vaccines. There is evidence that receiving wP as at least the first dose of pertussis-containing vaccine provides greater and more long-lived protection, irrespective of the nature of subsequent doses. This evidence will be reviewed together with the immunobiology associated with both vaccines, and the implications for pertussis control discussed.
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    Journal Title
    Expert Review of Vaccines
    Volume
    13
    Issue
    9
    DOI
    https://doi.org/10.1586/14760584.2014.944167
    Subject
    Clinical sciences
    Publication URI
    http://hdl.handle.net/10072/65155
    Collection
    • Journal articles

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