New allometric scaling relationships and applications for dose and toxicity extrapolation
Allometric scaling between metabolic rate, size, body temperature and other biological traits has found broad applications in ecology, physiology, and particularly in toxicology (e.g. inter-specific extrapolation). It was observed long ago that basal metabolic rate scales with body mass by a power function, whilst the scaling with temperature was recently proposed to be an exponential function. However, there has been increasing debates on the mass scaling exponent whether it should be 2/3, 3/4 or neither, and the exponential temperature scaling relationship was also questioned by many. This work reports three new scaling laws based on thermodynamic principles to characterize the relationship between these four biological traits. Good correlations were found with the new scaling laws, and no universal scaling exponent can be obtained. Results also demonstrated that individual extrapolation models should be built with the new scaling laws to obtain scaling exponent specific to the interested group of species, which can be applied for scaling and extrapolations in many areas.
International Journal of Toxicology
Environmental Chemistry (incl. Atmospheric Chemistry)
Environmental Engineering not elsewhere classified