• myGriffith
    • Staff portal
    • Contact Us⌄
      • Future student enquiries 1800 677 728
      • Current student enquiries 1800 154 055
      • International enquiries +61 7 3735 6425
      • General enquiries 07 3735 7111
      • Online enquiries
      • Staff phonebook
    View Item 
    •   Home
    • Griffith Research Online
    • Journal articles
    • View Item
    • Home
    • Griffith Research Online
    • Journal articles
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

  • All of Griffith Research Online
    • Communities & Collections
    • Authors
    • By Issue Date
    • Titles
  • This Collection
    • Authors
    • By Issue Date
    • Titles
  • Statistics

  • Most Popular Items
  • Statistics by Country
  • Most Popular Authors
  • Support

  • Contact us
  • FAQs
  • Admin login

  • Login
  • Cytotoxic evaluation of different composite resins and one glass-ionomer cement in cultures of human periodontal ligament cells. An in vitro study.

    Author(s)
    Silvestros, Spyros
    Mamalis, Anastasios
    Chronopoulos, Vasileios
    Baltzaki, G.
    Griffith University Author(s)
    Chronopoulos, Vasileios
    Year published
    2007
    Metadata
    Show full item record
    Abstract
    Objectives: Recent studies have demonstrated that periodontal ligament-derived (POL) cells have the potential to regenerate a complete periodontal connective tissue attachment apparatus on both root and artificial substrates. The major objecffve was to study the cytotoxic characteristics of dental materials conduCive to periodontal regeneration. An experimental model was established using markers 'Of mesenchymal origin (vimentin) and both fibroblastic (a-smooth muscle actin) and osteoblastic (alkaline phosphatase and osteocalcin activity) phenotype. Materials and methods: Cell viability and proliferation assay were used to ...
    View more >
    Objectives: Recent studies have demonstrated that periodontal ligament-derived (POL) cells have the potential to regenerate a complete periodontal connective tissue attachment apparatus on both root and artificial substrates. The major objecffve was to study the cytotoxic characteristics of dental materials conduCive to periodontal regeneration. An experimental model was established using markers 'Of mesenchymal origin (vimentin) and both fibroblastic (a-smooth muscle actin) and osteoblastic (alkaline phosphatase and osteocalcin activity) phenotype. Materials and methods: Cell viability and proliferation assay were used to evaluate cellular response in 24, 48 and 72 hours incubation period of treatment with the tested materials: one composite resin, one light-cured composite cement, one self-cured composite cement and one glassionomer cement. Results: Using Poisson regression analysis, it was found that within the first 24 hours only the light cured and the self cured composite cement revealed a statistically significant cytotoxic effect (p < 0.05). After 48 and 72 hours of treatment all materials proved to the prominent cytotoxic with the light cured composite cement to have the most dominant effect in all time intervals. ConClusions: All materials were found to be cytotoxic to human POL cells. However, both type of material and time, affected cell viability and proliferation.
    View less >
    Journal Title
    Journal of Contemporary Dentistry
    Volume
    27
    Issue
    3
    Publisher URI
    http://www.eso.gr/periodiko-sygxronos-odontiatros
    Subject
    Dentistry not elsewhere classified
    Publication URI
    http://hdl.handle.net/10072/65238
    Collection
    • Journal articles

    Footer

    Disclaimer

    • Privacy policy
    • Copyright matters
    • CRICOS Provider - 00233E

    Tagline

    • Gold Coast
    • Logan
    • Brisbane - Queensland, Australia
    First Peoples of Australia
    • Aboriginal
    • Torres Strait Islander