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dc.contributor.authorParatz, Jennifer D
dc.contributor.authorKenardy, Justin
dc.contributor.authorMitchell, Geoffrey
dc.contributor.authorComans, Tracy
dc.contributor.authorCoyer, Fiona
dc.contributor.authorThomas, Peter
dc.contributor.authorSingh, Sunil
dc.contributor.authorLuparia, Louise
dc.contributor.authorBoots, Robert J
dc.date.accessioned2017-05-03T14:22:03Z
dc.date.available2017-05-03T14:22:03Z
dc.date.issued2014
dc.identifier.issn2044-6055
dc.identifier.doi10.1136/bmjopen-2014-004966
dc.identifier.urihttp://hdl.handle.net/10072/65490
dc.description.abstractIntroduction Patients post sepsis syndromes have a poor quality of life and a high rate of recurring illness or mortality. Follow-up clinics have been instituted for patients postgeneral intensive care but evidence is sparse, and there has been no clinic specifically for survivors of sepsis. The aim of this trial is to investigate if targeted screening and appropriate intervention to these patients can result in an improved quality of life (Short Form 36 health survey (SF36V.2)), decreased mortality in the first 12 months, decreased readmission to hospital and/or decreased use of health resources. Methods and analysis 204 patients postsepsis syndromes will be randomised to one of the two groups. The intervention group will attend an outpatient clinic two monthly for 6 months and receive screening and targeted intervention. The usual care group will remain under the care of their physician. To analyse the results, a baseline comparison will be carried out between each group. Generalised estimating equations will compare the SF36 domain scores between groups and across time points. Mortality will be compared between groups using a Cox proportional hazards (time until death) analysis. Time to first readmission will be compared between groups by a survival analysis. Healthcare costs will be compared between groups using a generalised linear model. Economic (health resource) evaluation will be a within-trial incremental cost utility analysis with a societal perspective. Ethics and dissemination Ethical approval has been granted by the Royal Brisbane and Women's Hospital Human Research Ethics Committee (HREC; HREC/13/QRBW/17), The University of Queensland HREC (2013000543), Griffith University (RHS/08/14/HREC) and the Australian Government Department of Health (26/2013). The results of this study will be submitted to peer-reviewed intensive care journals and presented at national and international intensive care and/or rehabilitation conferences.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent1300541 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherB M J Group
dc.publisher.placeUnited Kingdom
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrome004966-1
dc.relation.ispartofpagetoe004966-6
dc.relation.ispartofjournalBMJ Open
dc.relation.ispartofvolume4
dc.rights.retentionY
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchOther health sciences
dc.subject.fieldofresearchcode3202
dc.subject.fieldofresearchcode4299
dc.titleIMPOSE (IMProving Outcomes after Sepsis)-the effect of a multidisciplinary follow-up service on health-related quality of life in patients postsepsis syndromes-a double-blinded randomised controlled trial: protocol
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.rights.copyright© The Author(s) 2014. The attached file is reproduced here in accordance with the copyright policy of the publisher. For information about this journal please refer to the journal’s website or contact the authors.
gro.hasfulltextFull Text
gro.griffith.authorComans, Tracy
gro.griffith.authorParatz, Jenny D.


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