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  • Changes in Mood, Depression and Suicidal Ideation after commencing Pregabalin for neuropathic pain

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    Author(s)
    Hall, T
    Shah, S
    Ng, B
    Feberwee, HM
    Dotchin, L
    Vandermost, M
    King, MA
    Griffith University Author(s)
    King, Michelle A.
    Year published
    2014
    Metadata
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    Abstract
    Background Pregabalin is a treatment option for patients with persistent neuropathic pain. Its use has been associated with changes in mood and the development of depression and/or suicidal ideation. Objective Case presentations were reviewed of five patients reporting changes in mood, depression and suicidal ideation from the first 50 (approximately) patients commenced on pregabalin at the clinic. Discussion Although these patients had a history of depression, their mood had been stable before commencing pregabalin. Soon after commencement they reported changes in mood, and development of depression and/or suicidal ideation, ...
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    Background Pregabalin is a treatment option for patients with persistent neuropathic pain. Its use has been associated with changes in mood and the development of depression and/or suicidal ideation. Objective Case presentations were reviewed of five patients reporting changes in mood, depression and suicidal ideation from the first 50 (approximately) patients commenced on pregabalin at the clinic. Discussion Although these patients had a history of depression, their mood had been stable before commencing pregabalin. Soon after commencement they reported changes in mood, and development of depression and/or suicidal ideation, which improved with dose reduction or cessation of pregabalin. Ultimately, all five patients ceased pregabalin treatment. Suicidal ideation is a recog-nised adverse effect of pregabalin. Patients should be warned of and monitored for deterioration in mood.
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    Journal Title
    Australian Family Physician
    Volume
    43
    Issue
    10
    Publisher URI
    http://www.racgp.org.au/afp/2014/october/changes-in-mood,-depression-and-suicidal-ideation-after-commencing-pregabalin-for-neuropathic-pain/
    Copyright Statement
    © 2014 Australian Family Physician. Reproduced with permission. Permission to reproduce must be sought from the publisher, The Royal Australian College of General Practitioners.
    Subject
    Clinical sciences
    Clinical pharmacology and therapeutics
    Publication URI
    http://hdl.handle.net/10072/65538
    Collection
    • Journal articles

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