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  • The important roles of miR-205 in normal physiology, cancers and as a potential therapeutic target

    Author(s)
    Vosgha, Haleh
    Salajegheh, Ali
    Smith, Robert Anthony
    Lam, Alfred King-Yin
    Griffith University Author(s)
    Lam, Alfred K.
    Ariana, Armin S.
    Year published
    2014
    Metadata
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    Abstract
    Evidences have demonstrated key mediatory roles of microRNA-205 (miR-205) in normal physiology and its aberrant expression in many cancers. Indeed, miR-205 has been identified as both a tumour suppressive and oncogenic miRNA playing crucial roles in tumourigenesis through regulating different cellular pathways such as cell survival, apoptosis, angiogenesis and metastasis. As a tumour suppressor, miR-205 acts as an inhibitor of cell proliferation, migration and invasion. On the other hand, as an oncogene, miR-205 promotes tumour initiation and development. All these functions act through different target genes in various types ...
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    Evidences have demonstrated key mediatory roles of microRNA-205 (miR-205) in normal physiology and its aberrant expression in many cancers. Indeed, miR-205 has been identified as both a tumour suppressive and oncogenic miRNA playing crucial roles in tumourigenesis through regulating different cellular pathways such as cell survival, apoptosis, angiogenesis and metastasis. As a tumour suppressor, miR-205 acts as an inhibitor of cell proliferation, migration and invasion. On the other hand, as an oncogene, miR-205 promotes tumour initiation and development. All these functions act through different target genes in various types of cancers. Also, miR-205 displays potential as a therapeutic target for different cancers. To conclude, miR-205 has important clinical and pathological correlations in different cancers and may act as a diagnostic and prognostic marker as well as new molecular target for cancer therapy.
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    Journal Title
    Current Cancer Drug Targets
    Volume
    14
    Issue
    7
    Publisher URI
    http://www.ingentaconnect.com/content/ben/ccdt/2014/00000014/00000007/art00004
    Subject
    Medicinal and biomolecular chemistry
    Oncology and carcinogenesis
    Pharmacology and pharmaceutical sciences
    Publication URI
    http://hdl.handle.net/10072/65570
    Collection
    • Journal articles

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