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  • The important roles of miR-205 in normal physiology, cancers and as a potential therapeutic target

    Author(s)
    Vosgha, Haleh
    Salajegheh, Ali
    Smith, Robert Anthony
    Lam, Alfred King-Yin
    Griffith University Author(s)
    Smith, Robert A.
    Lam, Alfred K.
    Ariana, Armin S.
    Vosgha, Haleh
    Year published
    2014
    Metadata
    Show full item record
    Abstract
    Evidences have demonstrated key mediatory roles of microRNA-205 (miR-205) in normal physiology and its aberrant expression in many cancers. Indeed, miR-205 has been identified as both a tumour suppressive and oncogenic miRNA playing crucial roles in tumourigenesis through regulating different cellular pathways such as cell survival, apoptosis, angiogenesis and metastasis. As a tumour suppressor, miR-205 acts as an inhibitor of cell proliferation, migration and invasion. On the other hand, as an oncogene, miR-205 promotes tumour initiation and development. All these functions act through different target genes in various types ...
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    Evidences have demonstrated key mediatory roles of microRNA-205 (miR-205) in normal physiology and its aberrant expression in many cancers. Indeed, miR-205 has been identified as both a tumour suppressive and oncogenic miRNA playing crucial roles in tumourigenesis through regulating different cellular pathways such as cell survival, apoptosis, angiogenesis and metastasis. As a tumour suppressor, miR-205 acts as an inhibitor of cell proliferation, migration and invasion. On the other hand, as an oncogene, miR-205 promotes tumour initiation and development. All these functions act through different target genes in various types of cancers. Also, miR-205 displays potential as a therapeutic target for different cancers. To conclude, miR-205 has important clinical and pathological correlations in different cancers and may act as a diagnostic and prognostic marker as well as new molecular target for cancer therapy.
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    Journal Title
    Current Cancer Drug Targets
    Volume
    14
    Issue
    7
    Publisher URI
    http://www.ingentaconnect.com/content/ben/ccdt/2014/00000014/00000007/art00004
    Subject
    Medicinal and biomolecular chemistry
    Oncology and carcinogenesis
    Pharmacology and pharmaceutical sciences
    Publication URI
    http://hdl.handle.net/10072/65570
    Collection
    • Journal articles

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